Second Harmonic Generation Interrogation of the Endonuclease APE1 Binding Interaction with G-Quadruplex DNA

Autor:	Aaron M. Fleming, Renee Tran, Carla A. Omaga, Shereen A. Howpay Manage, Cynthia J. Burrows, John C. Conboy
Rok vydání:	2022
Předmět:	G-Quadruplexes Vascular Endothelial Growth Factor A DNA Repair Second Harmonic Generation Microscopy DNA-(Apurinic or Apyrimidinic Site) Lyase DNA Endonucleases Analytical Chemistry
Zdroj:	Analytical Chemistry. 94:15027-15032
ISSN:	1520-6882 0003-2700
DOI:	10.1021/acs.analchem.2c02951
Popis:	The binding interaction between the DNA repair enzyme apurinic/apyrimidinic endonuclease-1 (APE1) with promoter G-quadruplex (G4) folds bearing an abasic site (AP) can serve as a gene regulatory switch during oxidative stress. Prior fluorescence-based analysis in solution suggested APE1 binds the
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e521bedc8656b3761c5745ce9720cf https://doi.org/10.1021/acs.analchem.2c02951 Zobrazit plný text záznamu