Postsynaptic CAMP pathway gates early LTP in hippocampal CA1 region
| Autor: | Tony Wong, Robert D. Blitzer, Emmanuel M. Landau, Ravi Iyengar, Rabin Nouranifar |
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| Rok vydání: | 1995 |
| Předmět: |
Time Factors
Neuroscience(all) Long-Term Potentiation Stimulation Neurotransmission Inhibitory postsynaptic potential Hippocampus Receptors N-Methyl-D-Aspartate Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Calmodulin Postsynaptic potential Cyclic AMP Phosphoprotein Phosphatases Animals Enzyme Inhibitors 030304 developmental biology 0303 health sciences Chemistry General Neuroscience Long-term potentiation Thionucleotides Electric Stimulation Rats nervous system Synapses NMDA receptor cAMP-dependent pathway Ion Channel Gating Neuroscience Postsynaptic density 030217 neurology & neurosurgery |
| Zdroj: | Neuron. 15(6):1403-1414 |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/0896-6273(95)90018-7 |
| Popis: | The role of the CAMP pathway in LTP was studied in the CAI region of hippocampus. Widely spaced trains of high frequency stimulation generated CAMP postsynaptically via NMDA receptors and calmodulin, consistent with the Ca 2+ /calmodulin-mediated stimulation of postsynaptic adenylyl cyclase. The early phase of LTP produced by the same pattern of high frequency stimulation was dependent on postsynaptic cAMP. However, synaptic transmission was not increased by postsynaptic application of CAMP. Early LTP became cAMP-independent when protein phosphatase inhibitors were injected postsynaptically. These observations indicate that in early UP the cAMP signaling pathway, instead of transmitting signals for the generation of LTP, gates UP through postsynaptic protein phosphatases. |
| Databáze: | OpenAIRE |
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