Impact of Allogeneic Hematopoietic Stem Cell Transplantation on the HIV Reservoir and Immune Response in 3 HIV-Infected Individuals
| Autor: | Orla Morrissey, Sam Milliken, Kersten K. Koelsch, Brad Milner, Sharon R Lewin, Sharon Avery, Sarah C. Sasson, David A. Cooper, Joseph K. Wong, Kazuo Suzuki, Robyn Tantau, William J. Hey-Nguyen, Steven A. Yukl, Derek J Chan, Jeffrey J. Post, Michael P. Busch, Sheila M. Keating, Angie N Pinto, Yin Xu, Katherine Marks, Thomas A Rasmussen, Solange Obeid, Mark S Taylor, John Zaunders, Chester F Pearson, Philipp Kaiser, Sarah Palmer, Bonnie Hiener, Anthony D. Kelleher, Michelle Bailey |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
CD4-Positive T-Lymphocytes Male Transplantation Conditioning medicine.medical_treatment HIV Infections Hematopoietic stem cell transplantation Regenerative Medicine Stem Cell Research - Nonembryonic - Human Antiretroviral Therapy Highly Active Pharmacology (medical) Viral biology Remission Induction Hematopoietic Stem Cell Transplantation virus diseases Middle Aged Viral Load surgical procedures operative Infectious Diseases HIV Antigens Treatment Outcome Public Health and Health Services HIV/AIDS RNA Viral Antibody Infection Viral load Adult Clinical Sciences Antiretroviral Therapy Article 03 medical and health sciences Young Adult Immune system Acquired immunodeficiency syndrome (AIDS) Clinical Research Virology Genetics medicine Humans Highly Active Transplantation business.industry Inflammatory and immune system DNA Stem Cell Research medicine.disease 030104 developmental biology Immunology DNA Viral biology.protein RNA business |
| Zdroj: | Journal of acquired immune deficiency syndromes (1999), vol 75, iss 3 |
| ISSN: | 1944-7884 |
| Popis: | Background: Allogeneic hematopoietic stem cell transplantation (HSCT) can lead to significant changes to the HIV reservoir and HIV immune responses, indicating that further characterization of HIV-infected patients undergoing HSCT is warranted. Methods: We studied 3 patients who underwent HSCT after either reduced intensity conditioning or myeloablative conditioning regimen. We measured HIV antigens and antibodies (Ag/Ab), HIV-specific CD4+ T-cell responses, HIV RNA, and DNA in plasma, peripheral blood mononuclear cells, isolated CD4+ T cells from peripheral blood, and lymph node cells. The patients remained on antiretroviral therapy throughout the follow-up period. Results: All patients have been in continued remission for 4–6 years post-HSCT. Analyses of HIV RNA and DNA levels showed substantial reductions in HIV reservoir–related measurements in all 3 patients, changes in immune response varied with pronounced reductions in 2 patients and a less dramatic reduction in 1 patient. One patient experienced unexpected viral rebound 4 years after HSCT. Conclusions: These 3 cases highlight the substantial changes to the HIV reservoir and the HIV immune response in patients undergoing allogeneic HSCT. The viral rebound observed in 1 patient indicates that replication competent HIV can re-emerge several years after HSCT despite these marked changes. |
| Databáze: | OpenAIRE |
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