Epidemiology of Candida species infections in critically ill non-immunosuppressed patients
| Autor: | Philippe Eggimann, Didier Pittet, Jorge Garbino |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Candidiasis/drug therapy/ epidemiology/physiopathology Antifungal Agents Disease Microbial Sensitivity Tests Global Health Species Specificity Risk Factors Intensive care Epidemiology medicine Global health Humans Intensive care medicine Candida/ drug effects/isolation & purification Cross Infection/drug therapy/ epidemiology/physiopathology Candida ddc:616 Cross Infection business.industry Critically ill Incidence (epidemiology) Incidence Antifungal Agents/ therapeutic use Candidiasis Intensive Care Units Infectious Diseases Reduced susceptibility Population Surveillance World Health Candida spp business |
| Zdroj: | The Lancet Infectious Diseases, Vol. 3, No 11 (2003) pp. 685-702 |
| ISSN: | 1473-3099 |
| Popis: | A substantial proportion of patients become colonised with Candida spp during hospital stay, but only few subsequently develop severe infection. Clinical signs of severe infection manifest early but lack specificity until late in the course of the disease, thus representing a particular challenge for diagnosis. Mostly nosocomial, invasive candidiasis occurs in only 1-8% of patients admitted to hospitals, but in around 10% of patients housed in intensive care units where it can represent up to 15% of all nosocomial infections. We review the epidemiology of invasive candidiasis in non-immunocompromised, critically ill patients with special emphasis on disease trends over time, pathophysiology, diagnostic approach, risk factors, and impact. Recent epidemiological data suggesting that the emergence of non-albicans candida strains with reduced susceptibility to azoles, previously linked to the use of new antifungals for empiric and prophylactic therapy in immunocompromised patients, may not have occurred in the critically ill. Management of invasive candidiasis in these patients will be addressed in the December issue of The Lancet Infectious Diseases. |
| Databáze: | OpenAIRE |
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