Inter-individual differences in the responses to aerobic exercise in Alzheimer's disease: Findings from the FIT-AD trial
| Autor: | Michelle A. Mathiason, Dereck Salisbury, Fang Yu |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Population Walk Test Physical Therapy Sports Therapy and Rehabilitation Disease lcsh:GV557-1198.995 03 medical and health sciences Cognition Oxygen Consumption 0302 clinical medicine Moderate dementia Alzheimer Disease medicine Humans Aerobic exercise Dementia Orthopedics and Sports Medicine 030212 general & internal medicine lcsh:Sports medicine education Exercise Aged lcsh:Sports Aged 80 and over education.field_of_study Physical activity business.industry VO2 max 030229 sport sciences Alzheimer's disease medicine.disease Test (assessment) Socioeconomic Factors Physical Fitness Physical therapy Educational Status Female Original Article sense organs Independent Living lcsh:RC1200-1245 business human activities |
| Zdroj: | Journal of Sport and Health Science Journal of Sport and Health Science, Vol 10, Iss 1, Pp 65-72 (2021) |
| ISSN: | 2095-2546 |
| Popis: | Highlights • There were no differences in aerobic fitness and cognition between the intervention and the control groups. • The intervention group had a substantially greater standard deviation in the changes in aerobic fitness and cognition than the control group, indicating the presence of true interindividual differences in aerobic-fitness and cognitive responses to aerobic exercise. • Exercise attendance was not associated with the changes in aerobic fitness or cognition. Background Despite the strong evidence of aerobic exercise as a disease-modifying treatment for Alzheimer's disease (AD) in animal models, its effects on cognition are inconsistent in human studies. A major contributor to these findings is inter-individual differences in the responses to aerobic exercise, which was well documented in the general population but not in those with AD. The purpose of this study was to examine inter-individual differences in aerobic fitness and cognitive responses to a 6-month aerobic exercise intervention in community-dwelling older adults with mild-to-moderate dementia due to AD. Methods This study was a secondary analysis of the Effects of Aerobic Exercise for Treating Alzheimer's Disease (FIT-AD) trial data. Aerobic fitness was measured by the shuttle walk test (SWT), the 6-min walk test (6MWT), and the maximal oxygen consumption (VO2max) test, and cognition by the AD Assessment Scale-Cognition (ADAS-Cog). Inter-individual differences were calculated as the differences in the standard deviation of 6-month change (SDR) in the SWT, 6MWT, VO2max, and ADAS-Cog between the intervention and control groups. Results Seventy-eight participants were included in this study (77.4 ± 6.3 years old, mean ± SD; 15.7 ± 2.8 years of education; 41% were female). VO2max was available for 26 participants (77.7 ± 7.1 years old; 14.8 ± 2.6 years of education; 35% were female). The SDR was 37.0, 121.1, 1.7, and 2.3 for SWT, 6MWT, VO2max, and ADAS-Cog, respectively. Conclusion There are true inter-individual differences in aerobic fitness and cognitive responses to aerobic exercise in older adults with mild-to-moderate dementia due to AD. These inter-individual differences likely underline the inconsistent cognitive benefits in human studies. Graphical abstract Image, graphical abstract |
| Databáze: | OpenAIRE |
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