Trends and causes of mortality in a population-based cohort of HIV-infected adults in Spain: comparison with the general population
| Autor: | Carmen Ezpeleta, Jesús Repáraz, Conchi Moreno-Iribas, Aitziber Aguinaga, María Gracia, María Rivero, Y Floristán, Carmen Fontela, Ramón San Miguel, Ujué Fresán, Jesús Castilla |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine 030106 microbiology Population lcsh:Medicine Diseases HIV Infections Disease Article 03 medical and health sciences Population based cohort 0302 clinical medicine Cause of Death medicine Humans 030212 general & internal medicine Mortality lcsh:Science education Aged Cause of death education.field_of_study Multidisciplinary business.industry Mortality rate lcsh:R Health care Case-control study Middle Aged medicine.disease Substance abuse Risk factors Spain Case-Control Studies Cohort lcsh:Q Female business Demography |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-65841-0 |
| Popis: | Combination antiretroviral therapy reduces mortality of HIV-infected persons. In Spain, where this therapy is widely available, we aim to evaluate mortality trends and causes of death in HIV-infected adults, and to estimate the excess mortality compared to the general population. From 1999 to 2018 mortality by causes was analyzed in a population-based cohort of adults aged 25 to 74 years diagnosed with HIV infection in Spain. Observed deaths and expected deaths according mortality in the general population of the same sex and age were compared using standardized mortality ratios (SMRs). HIV-infected people increased from 839 in 1999–2003 to 1059 in 2014–2018, median age increased from 37 to 47 years, the annual mortality rate decreased from 33.5 to 20.7 per 1000 person-years and the proportion of HIV-related deaths declined from 64% to 35%. HIV-related mortality declined from 21.4 to 7.3 (p |
| Databáze: | OpenAIRE |
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