Microvascular polytetrafluoroethylene (Gore-Tex) grafts in the infrarenal rat aorta
| Autor: | Torsten Holmin, Peter C. G. Löwenhielm, Else B. Ribbe |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Aortic Diseases Biocompatible Materials Constriction Pathologic Anastomosis Prosthesis Aortography chemistry.chemical_compound Postoperative Complications medicine.artery medicine Animals Aorta Abdominal Aorta Polytetrafluoroethylene medicine.diagnostic_test business.industry External iliac artery Rats Inbred Strains Microsurgery medicine.disease Surgery Blood Vessel Prosthesis Rats Stenosis surgical procedures operative chemistry Angiography business |
| Zdroj: | Microsurgery. 8(2) |
| ISSN: | 0738-1085 |
| Popis: | To evaluate the use of microvascular prosthetic grafts, the infrarenal aorta in 33 male Sprague-Dawley rats was replaced by an interposition graft of PTFE (polytetrafluoroethylene, Gore-Tex®). Three groups of experimental animals were studied: Group A consisted of rats with 7-mm-long grafts, group B consisted of rats with 20-mm-long grafts, and group C consisted of rats with 20-mm-long grafts and ligatures of one common iliac and one external iliac artery. In group A all grafts (11/11) were patent after varying observation periods (6–92 days, median value 28 days, mean value 49 days). In group B all grafts but one (13/14) were patent (0–201 days, median value 198 days, mean value 118 days). In group C two grafts occluded immediately postoperatively, whereas the remaining six were patent (0–24 days, median and mean values 9 days). Twelve of 13 grafts observed for 3 months or more remained patent. There were no signs of infection. Angiography did not reveal any stenosis in the anastomoses of patent grafts. Light microscopy demonstrated a good adaptation between the grafts and the aorta in all animals. In the short grafts observed for 3 months and in the long grafts observed for 6 months, the luminal surfaces were completely covered by endothelial-like cells. In the occluded graft in group B, a stenosis was demonstrated in one of the anastomoses. This was not found in any other specimen. The results of this study document the possibility of using PTFE grafts of 1 mm diameter in experimental microvascular position. |
| Databáze: | OpenAIRE |
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