Predictors of Sustained Response With Tofacitinib Therapy in Patients With Ulcerative Colitis
| Autor: | William J Sandborn, Alessandro Armuzzi, Giuseppina Liguori, Peter M Irving, Ala I Sharara, Rajiv Mundayat, Nervin Lawendy, John C Woolcott, Silvio Danese |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Inflammatory Bowel Diseases. 28:1338-1347 |
| ISSN: | 1536-4844 1078-0998 |
| Popis: | Background Tofacitinib is an oral, small molecule JAK inhibitor for the treatment of ulcerative colitis. We evaluate baseline characteristics as predictors of sustained response and remission in patients with ulcerative colitis receiving tofacitinib maintenance therapy. Methods Patients with clinical response following OCTAVE Induction 1 and 2 entered OCTAVE Sustain and were rerandomized to receive tofacitinib 5 or 10 mg twice daily or placebo. Baseline characteristics were stratified by week 52 efficacy endpoints (remission, sustained remission, clinical response, sustained clinical response). Associations between baseline characteristics and efficacy endpoints were evaluated using logistic regression analyses. Results Overall, 170 of 487 (34.9%) patients were in remission at week 52. In multivariable modeling, endoscopic subscore at baseline of OCTAVE Induction 1 and 2 (2 vs 3; odds ratio [OR], 1.60; 95% confidence interval [CI], 1.06-2.44]), partial Mayo score ( Conclusion Patients with greater clinical improvement after 8 weeks of tofacitinib induction therapy are more likely to maintain response or remission with tofacitinib regardless of dose received during maintenance, highlighting the importance of a robust response to induction therapy. |
| Databáze: | OpenAIRE |
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