Autoantibodies in nonautoimmune individuals during infections
| Autor: | Ronald A. Asherson, Tanja Kveder, Tatiana Berlin, Yair Levy, Miri Blank, Gisele Zandman-Goddard, Torsten Matthias, Sham Singh, Ingrid Weis, Abigail Fraser, Boris Gilburd, Yehuda Shoenfeld, Sascha Pfeiffer, Elias Toubi, Blaž Rozman, Janja Lukac, Tal Sapir |
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| Předmět: |
Anti-nuclear antibody
Enzyme-Linked Immunosorbent Assay Antibodies Viral Infections medicine.disease_cause General Biochemistry Genetics and Molecular Biology Immune system History and Philosophy of Science medicine Animals Humans Parasites Autoantibodies Autoimmune disease biology General Neuroscience Molecular Mimicry Autoantibody Hepatitis A Hepatitis B medicine.disease Antibodies Bacterial Virology Molecular mimicry Immunology biology.protein Antibody |
| Zdroj: | University of Bristol-PURE |
| Popis: | Infections can act as environmental triggers inducing or promoting autoimmune disease in genetically predisposed individuals. Identification of microbial peptides similar to self-tissues may by molecular mimicry, provide the inducing mechanism for an immune response. The aim of this study was to identify autoantibodies (autoAbs) in nonautoimmune individuals during acute bacterial, viral, or parasitic infections. Specific Abs or specific infections with an increased autoAb load may shed insight into the mechanisms of autoimmune disease. Sera from 88 patients with acute infections (41 bacterial, 23 viral, 17 parasitic, and 7 rickettsial) were tested by the ELISA method for antinuclear antibodies (ANA) 8 Pro, and Abs to thyroid peroxidase (TPO), thyroglobulin, phospholipids, annexin-V, laminin, anti-Saccharomyces cervisiae (ASCA), and prothrombin, along with 80 normal controls. Elevated titers of Abs to annexin-V and prothrombin were the most prevalent in viral, parasitic, and rickettsial infections and to laminin in viral and parasitic infections. Elevated titers of ASCA and ANA were found in viral and bacterial infections. Antiphospholipid Abs were found in parasitic and Q-fever infections. Thirty-four individuals harbored elevated titers of at least two Abs. An autoAb burden was detected in individuals with hepatitis A, hepatitis B, toxoplasma or Q-fever infections. In nonautoimmune individuals with various (bacterial, viral, parasitic, and rickettsial) infections, elevated titers of Abs to annexin-V, prothrombin, laminin, ASCA, ANA, and phospholipids were most frequently detected. |
| Databáze: | OpenAIRE |
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