Curative Effects of Dendritic Cells Combined with Cytokine-Induced Killer Cells in Patients with Malignant Pericardial Effusion
| Autor: | Rusen Zhao, Sheng Wang, Ming Sun, Yuzhong Cui, Hongmin Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Pleural Neoplasms Chest pain Pericardial effusion Gastroenterology Immunotherapy Adoptive Pericardial Effusion law.invention Heart Neoplasms 03 medical and health sciences 0302 clinical medicine Cytokine-Induced Killer Cells Randomized controlled trial law Clinical Research Internal medicine medicine Humans Cisplatin Cytokine-induced killer cell business.industry Remission Induction Interleukin General Medicine Immunotherapy Dendritic Cells Middle Aged medicine.disease Bone marrow suppression 030220 oncology & carcinogenesis Quality of Life Interleukin-2 Female medicine.symptom business 030215 immunology medicine.drug |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 1234-1010 |
| Popis: | BACKGROUND To determine the effects of dendritic cells (DCs) and cytokine-induced killer (CIK) cells in patients with malignant pericardial effusion. MATERIAL AND METHODS All patients underwent pericardial puncture and indwelling catheter insertion. After pericardial drainage, the 16 patients in the treatment group received an infusion of 20 mL DCs and CIK cells (>1.0×10¹° cells) and 500,000 U interleukin (IL)-2 for 3 successive days. The 15 control-group patients received 30 mg/m² cisplatin and 500,000 U IL-2 for 3 successive days. The treatment effects were assessed using imaging data. RESULTS The total efficiency and complete remission rates were higher in the treatment group than in the control group at 4 weeks (total efficiency: 87.50% vs. 73.33%; complete remission: 62.50% vs. 46.67%) and 3 months after the treatment (total efficiency: 81.25% vs. 66.67%; complete remission: 50.00% vs. 40.00%; P |
| Databáze: | OpenAIRE |
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