Intact Human Immunodeficiency Virus (HIV) Reservoir Estimated by the Intact Proviral DNA Assay Correlates With Levels of Total and Integrated DNA in the Blood During Suppressive Antiretroviral Therapy

Autor:	Nicolas Chomont, Shih Lin Goh, Carolyn Bahnck-Teets, Paul Zuck, Bonnie J. Howell, Steven M. Lada, Amanda C Sciorillo, Douglas D. Richman, Mohammad Damra, Mohamed Abdel-Mohsen, Agnieszka Mackiewicz, Jay R. Kostman, Emmanouil Papasavvas, Amélie Pagliuzza, Pablo Tebas, Kwasi Gyampoh, Matthew Fair, Kenneth Lynn, Zhe Yuan, Karam Mounzer, Livio Azzoni, Guoxin Wu, Brian N Ross, Luis J. Montaner, Daniel J. Holder
Rok vydání:	2020
Předmět:	CD4-Positive T-Lymphocytes 0301 basic medicine Microbiology (medical) viruses Human immunodeficiency virus (HIV) HIV Infections Proviral dna medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Proviruses Humans Medicine business.industry virus diseases Provirus Antiretroviral therapy Virology Virus Latency 030104 developmental biology Infectious Diseases chemistry DNA Viral HIV-1 Brief Reports business 030217 neurology & neurosurgery DNA
Zdroj:	Clin Infect Dis
ISSN:	1537-6591 1058-4838
Popis:	Accurate characterization of the human immunodeficiency virus (HIV) reservoir is imperative to develop an effective cure. HIV was measured in antiretroviral therapy-suppressed individuals using the intact proviral DNA assay (IPDA), along with assays for total or integrated HIV DNA, and inducible HIV RNA or p24. Intact provirus correlated with total and integrated HIV.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9dac788321df38f3df5e7faf27e9ea5 https://doi.org/10.1093/cid/ciaa809 Zobrazit plný text záznamu