Prenatal diagnosis of birth defects and termination of pregnancy in Hunan Province, China
| Autor: | Donghua Xie, Changbiao Liang, Zhiyu Liu, Hua Wang, Yueyun Xiang, Lili Xiong, Aihua Wang, Fanjuan Kong, Haoxian Li |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine China medicine.medical_specialty Gestational Age Prenatal diagnosis 030105 genetics & heredity Congenital Abnormalities Congenital hydrocephalus Encephalocele Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy Prenatal Diagnosis Conjoined twins Anencephaly Prevalence medicine Humans Genetics (clinical) Fetus 030219 obstetrics & reproductive medicine business.industry Obstetrics Infant Newborn Pregnancy Outcome Obstetrics and Gynecology Gestational age Abortion Induced medicine.disease Female business Abortion Eugenic Maternal Age |
| Zdroj: | Prenatal Diagnosis. 40:925-930 |
| ISSN: | 1097-0223 0197-3851 |
| DOI: | 10.1002/pd.5648 |
| Popis: | Objective The aim of this study was to analyse the characteristics of the prenatal diagnosis (PD) of birth defects (BDs) and termination of pregnancy (TOP) for fetal anomalies and to suggest perinatal management. Methods BD surveillance data were collected from 52 registered hospitals in Hunan between 2015 and 2018. The PD and TOP rates of BDs were calculated to examine the associations between infant sex, maternal age, and region. Results From 2015 to 2018, a total of 18 931 fetuses with BDs were identified, of which 10 299 fetuses (54.4%) were diagnosed prenatally and 9343 pregnancies (90.7% among PDs and 49.3% among BDs) were terminated. The mean gestational age at diagnosis for fetuses with BDs was 25.1 ± 5.9 weeks and showed a downward trend over the study period. The average PD rate of the BDs was higher in rural areas than in urban areas (58.1% vs 50.3%), higher for female than male fetuses (57.25% vs 48.92%), and higher for mothers older than age 35 than for those younger (58.62% vs 53.69%). The average TOP rate of fetuses with BDs in rural areas was higher than that in urban areas (91.99% vs 89.12%) and decreased with increasing maternal age ( x trend 2 = 7.926, P = .005). The five BDs with the highest PD rates were conjoined twins (100%), anencephaly (97.87%), congenital hydrocephalus (97.66%), chromosomal malformation (96.07%), and encephalocele (95.54%). The five BDs with the highest TOP rates among the PDs were conjoined twins (100%), exstrophy of the urinary bladder (100%), chromosomal malformation (98.09%), encephalocele (98%), and anencephaly (97.28%). Conclusions More than half of BDs were diagnosed prenatally, with the majority diagnosed at less than 28 gestational weeks. The TOP rates following PD in Hunan Province were high, especially for rural and younger mothers. The findings suggest a need for high-quality, targeted counselling following PD. |
| Databáze: | OpenAIRE |
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