Assessment of liver fibrosis by ultrasound elastography and contrast-enhanced ultrasound: a randomized prospective animal study
| Autor: | Jinzhen Song, Yujun Shi, Wenwu Ling, Tingting Qiu, Hong Wang, Gang Guo, Yan Luo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Liver Cirrhosis
medicine.medical_specialty Original General Biochemistry Genetics and Molecular Biology 030218 nuclear medicine & medical imaging 03 medical and health sciences chemistry.chemical_compound Random Allocation 0302 clinical medicine diagnostic performance Fibrosis medicine Animals Prospective Studies Stage (cooking) Prospective cohort study liver fibrosis Ultrasonography General Veterinary medicine.diagnostic_test Receiver operating characteristic business.industry Ultrasound General Medicine medicine.disease Image Enhancement Disease Models Animal chemistry Liver ROC Curve ultrasound elastography Carbon tetrachloride Elasticity Imaging Techniques 030211 gastroenterology & hepatology Animal Science and Zoology Elastography Radiology Rabbits business Nuclear medicine contrast-enhanced ultrasound Contrast-enhanced ultrasound portal vein |
| Zdroj: | Experimental Animals |
| ISSN: | 1881-7122 1341-1357 |
| Popis: | This study aimed to assess liver fibrosis by contrast-enhanced ultrasound (CEUS) and point shear-wave elastography (pSWE) in rabbits and compare the performance of the two techniques. Eighty rabbits were divided into experimental (n=60) and control group (n=20). In the experimental group, liver fibrosis (F1-F4) was induced by subcutaneous injection of carbon tetrachloride. CEUS and pSWE of the liver was performed for the two groups at a 4-week interval for 40 weeks. The portal vein rise time (PV-RT), time to peak (PV-TTP), mean transit time (PV-MTT) and the maximum signal intensity (PV-Imax) were analyzed with time-intensity curves (TICs). Liver stiffness value (LSV) was obtained through pSWE. Histologic examination of liver specimens of the rabbits was performed to evaluate the fibrosis stage. PV-RT, PV-TTP, PV-Imax and LSV were significantly different among five liver fibrosis stages (F0-F4) (P |
| Databáze: | OpenAIRE |
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