The impact of race/ethnicity on upstaging and/or upgrading rates among intermediate risk prostate cancer patients treated with radical prostatectomy
| Autor: | Zhe Tian, Claudia Collà Ruvolo, Nicola Fossati, Felix K.-H. Chun, Pierre I. Karakiewicz, Vincenzo Mirone, Francesco Montorsi, Fred Saad, Giorgio Gandaglia, Alberto Briganti, Markus Graefen, Shahrokh F. Shariat, Luigi Nocera, Christoph Würnschimmel, Mike Wenzel |
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| Přispěvatelé: | Nocera, Luigi, Wenzel, Mike, Collà Ruvolo, Claudia, Würnschimmel, Christoph, Tian, Zhe, Gandaglia, Giorgio, Fossati, Nicola, Chun, Felix K H, Mirone, Vincenzo, Graefen, Marku, Saad, Fred, Shariat, Shahrokh F, Montorsi, Francesco, Briganti, Alberto, Karakiewicz, Pierre I |
| Rok vydání: | 2021 |
| Předmět: |
African-American
Oncology PCa medicine.medical_specialty Asian Prostatectomy business.industry Urology medicine.medical_treatment Odds ratio Lower risk Logistic regression medicine.disease SEER Prostate cancer Internal medicine Epidemiology medicine Stage (cooking) Hispanic/Latino Intermediate risk business |
| Zdroj: | World Journal of Urology. 40:103-110 |
| ISSN: | 1433-8726 0724-4983 |
| Popis: | Race/ethnicity may predispose to less favorable prostate cancer characteristics in intermediate risk prostate cancer (IR PCa) patients. We tested this hypothesis in a subgroup of IR PCa patients treated with radical prostatectomy (RP). We relied on the Surveillance, Epidemiology and End Results 2004–2016. The effect of race/ethnicity was tested in univariable and multivariable logistic regression analyses predicting upstaging (pT3+/pN1) and/or upgrading (Gleason Grade Group [GGG] 4–5) at RP. Of 20,391 IR PCa patients, 15,050 (73.8%) were Caucasian, 2857 (14.0%) African-American, 1632 (8.0%) Hispanic/Latino and 852 (4.2%) Asian. Asian patients exhibited highest age (64 year), highest PSA (6.8 ng/ml) and highest rate of GGG3 (31.9%). African-Americans exhibited the highest percentage of positive cores at biopsy (41.7%) and the highest proportion of NCCN unfavorable risk group membership (54.6%). Conversely, Caucasians exhibited the highest proportion of cT2 stage (35.6%). In univariable analyses, Hispanic/Latinos exhibited the highest rates of upstaging/upgrading among all race/ethnicities, in both favorable and unfavorable groups, followed by Asians, Caucasians and African-Americans in that order. In multivariable analyses, Hispanic/Latino race/ethnicity represented an independent predictor of higher upstaging and/or upgrading in favorable IR PCa (odds ratio [OR] 1.27, p |
| Databáze: | OpenAIRE |
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