The bronze kidney: membranous glomerulonephritis associated with iron overload
| Autor: | Adrian Jennings, Verena Broecker, John Bradley, Arash Vaziri |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Iron Overload Biopsy Ferroportin Peripheral edema Kidney Glomerulonephritis Membranous Gastroenterology Article Diagnosis Differential Phlebotomy Internal medicine medicine Humans Proteinuria biology medicine.diagnostic_test Transferrin saturation business.industry Glomerulonephritis General Medicine Middle Aged medicine.disease medicine.anatomical_structure Liver biopsy biology.protein Renal biopsy medicine.symptom business |
| Zdroj: | Case Reports. 2015:bcr2014204830-bcr2014204830 |
| ISSN: | 1757-790X |
| DOI: | 10.1136/bcr-2014-204830 |
| Popis: | A 55-year-old man with a history of diabetes mellitus, hypertension and hypercholesterolaemia developed increasing peripheral oedema over the course of several months. He was found to have nephrotic range proteinuria (15.7 g/24 h). His renal ultrasound scan was normal and the autoimmune screen was negative. His renal biopsy demonstrated evidence of membranous glomerulonephritis and increased iron deposition. At this juncture, a serum ferritin was checked which showed an initial value 933 µg/L with transferrin saturation at 96.6%. A subsequent liver biopsy also showed evidence of iron overload but without fibrotic changes. Genetic studies including C282Y HFE, ferroportin and DMT1 studies were also negative. He was subsequently treated with interval venesection which was associated with significant symptomatic and biochemical evidence of improvement in oedema and proteinuria. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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