Human Herpesvirus 8 seroprevalence among blood donors in Mali
| Autor: | Gervillien Arnold Malonga, Sidi Dienta, Fatoumata Tata Traore, Zalihatou Maiga, Alhassane Ba, Ousmane Faye, Elodie Chicaud, Stéphane Marot, Vincent Calvez, Anne‐Geneviève Marcelin, Aude Jary, Almoustapha I. Maiga |
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| Přispěvatelé: | Sorbonne Université, INSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique, Assistance Publique – Hôpitaux de Paris (AP‑HP), Hôpitaux Universitaires Pitié‑Salpêtrière ‑ Charles Foix, Laboratoire de Virologie, Paris, France., Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU) |
| Rok vydání: | 2022 |
| Předmět: |
Hepatitis B virus
[SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology Blood Donors HIV Infections Antibodies Viral Hepatitis B Mali Hepatitis C Infectious Diseases Cross-Sectional Studies [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology Seroepidemiologic Studies Virology [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Herpesvirus 8 Human Humans Syphilis |
| Zdroj: | Journal of medical virology. 94(9) |
| ISSN: | 1096-9071 |
| Popis: | In sub-Saharan Africa, the Human Herpesvirus 8 (HHV-8) is endemic but with disparities between regions and population studied. Although the virus remains mostly latent, there is some evidence that blood transfusion may represents one of the transmission way for this virus. Here, we evaluated HHV-8 seroprevalence among blood donors in Mali. This cross-sectional study recruited blood donors from the Blood Transfusion Center at Gabriel Touré Hospital, Bamako. Serum was used for the detection of latent HHV-8 immunoglobulin G directed against latent associated nuclear antigen 1 by an indirect immunofluorescence assay. Human immunodeficiency virus 1 (HIV-1), Hepatitis B Virus (HBV), HCV, and Treponema pallidum were also screened. HHV-8 seroprevalence was 10.4% in Malian blood donors. None of the sociodemographic characteristics were associated with HHV-8 infection, although there is a tendency of a higher HHV-8 seroprevalence among participants living in Bamako than those not living there. One individual had coinfection HHV-8/HBV, another HHV-8/HCV while another had HCV and T. pallidum. None has been tested positive for HIV infection. This intermediate seroprevalence in Malian blood donors suggests that the risk of HHV-8 transmission by transfusion should be considered. Further investigations are needed to assess impact of HHV-8 in polytransfused patients residing in an endemic area for this virus. |
| Databáze: | OpenAIRE |
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