Kinetics of CD4 cells after discontinuation of antiretroviral therapy in patients with virological failure and a CD4 cell count greater than 500 cells/μl
| Autor: | Ada Bertoli, Carlo Federico Perno, Roberto Bugarini, Roberta D'Arrigo, Roberto Esposito, Andrea Bedini, Vanni Borghi, Cristina Mussini, Andrea Antinori, Mongiardo N, Andrea Cossarizza |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
CD4 HIV AIDS medicine.medical_treatment Immunology Gastroenterology Internal medicine Immunopathology medicine Immunology and Allergy Sida Chemotherapy biology business.industry Lamivudine biology.organism_classification Resistance mutation Discontinuation Surgery Infectious Diseases Viral disease business Viral load medicine.drug |
| Popis: | After a median of 37 months on antiretroviral therapy, 16 patients were asked to discontinue treatment instead of changing it. After a median observation time of 10.5 months, most patients experienced a rapid and progressive decrease in their CD4 cell count, even without a high viral load rebound. This decline was unrelated to the CD4 cell count and HIV-RNA values at interruption, but was more profound in patients in whom the M184V mutation had disappeared after lamivudine discontinuation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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