Cardiometabolic risk factors in Turkish children with hepatosteatosis
| Autor: | Mehmet Agirbasli, Gülçin Durukan Gunaydın, Mine Aslan, Ramazan Ömer Yazar, Ahmet Aslan, Servet Erdemli, Adnan Kabaalioglu |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Turkey Overweight Gastroenterology Non-alcoholic Fatty Liver Disease Risk Factors Internal medicine medicine Prevalence Humans Child Retrospective Studies Cardiometabolic risk Metabolic Syndrome business.industry Anthropometry medicine.disease Impaired fasting glucose Obesity Blood pressure Cross-Sectional Studies Cardiovascular Diseases Pediatrics Perinatology and Child Health Female medicine.symptom Metabolic syndrome Steatosis business |
| Zdroj: | The Turkish journal of pediatrics. 61(5) |
| ISSN: | 2791-6421 |
| Popis: | Aslan A, Erdemli S, Durukan Gunaydin G, Aslan M, Yazar RO, Kabaalioglu A, Agirbasli MA. Cardiometabolic risk factors in Turkish children with hepatosteatosis. Turk J Pediatr 2019; 61: 714-722. We aimed to investigate the prevalence of cardiometabolic (CM) risk factors (impaired fasting glucose ( > 100 mg/dL), high blood pressure, overweight or obesity, high serum triglycerides (TG) and low serum high-density lipoprotein cholesterol levels) in children with hepatosteatosis detected by abdominal ultrasound. Children whom ultrasound examination revealed hepatic steatosis were included in the study. Medical records, anthropometric and biochemical parameters were reviewed for the presence of the CM risk factors. Presence of ≥3 risk factors was defined as metabolic syndrome (MS). One hundred and forty-eight children and adolescents (67 boys, 81girls, and mean age 12.1±2.7 years) with hepatosteatosis were included. Sonographic hepatosteatosis grades of 1, 2 and 3 were observed in 111 (75%), 33 (22.3%), and 4 (2.7%) subjects, respectively. MS was observed in 36 patients (24.3%). The number of CM risk factors and degree of hepatic steatosis were correlated (r=0.183, p=0.026). Serum TG levels in girls and age in boys were significantly associated with the presence of medium to severe hepatosteatosis (grades 2 or 3) (R2=.342, =.040 and R2=.538, p=.001, respectively). CM risk factors and MS are common in children with hepatosteatosis. The presence and grade of hepatosteatosis on ultrasound can be used as surrogate markers of MS and CM risk in children. |
| Databáze: | OpenAIRE |
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