Reduced susceptibilities to biocides and resistance to antibiotics in food-associated bacteria following exposure to quaternary ammonium compounds

Autor: P. Le Grandois, Martine Denis, Christophe Soumet, A. Le Roux, D. Méheust, Christine Pissavin, B. Frémaux, C. Feurer, Pierre Maris
Přispěvatelé: Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Département Génie Biologique / IUT de Saint-Brieuc, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Institut du Porc (IFIP), Laboratoire de Ploufragan - Plouzané, IUT de Saint-Brieuc, Université de Rennes (UR)
Rok vydání: 2016
Předmět:
0301 basic medicine
désinfectant
Biocide
antibiotic resistance
Cefotaxime
medicine.drug_class
Disinfectant
030106 microbiology
Antibiotics
Ceftazidime
résistance aux antibiotiques
Biology
Applied Microbiology and Biotechnology
susceptibility
Microbiology
03 medical and health sciences
Benzalkonium chloride
Antibiotic resistance
Salmonella
Drug Resistance
Bacterial
ammonium quaternaire
Escherichia coli
medicine
bacteria
bactérie
2. Zero hunger
biocide
General Medicine
Antimicrobial
Listeria monocytogenes
Anti-Bacterial Agents
3. Good health
Quaternary Ammonium Compounds
food safety
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
sécurité alimentaire
13. Climate action
Food Microbiology
quaternary ammonium
Benzalkonium Compounds
disinfectant
Disinfectants
Biotechnology
medicine.drug
Zdroj: Journal of Applied Microbiology
Journal of Applied Microbiology, Wiley, 2016, 121 (5), pp.1275-1281. ⟨10.1111/jam.13247⟩
Journal of Applied Microbiology, 2016, 121 (5), pp.1275-1281. ⟨10.1111/jam.13247⟩
ISSN: 1364-5072
1365-2672
Popis: Aims Our aim was to assess the effects of step-wise exposure to didecyl dimethyl ammonium chloride (DDAC) on the antimicrobial (antibiotics and biocides) susceptibilities of food-associated bacterial strains. Methods and Results Adaptive responses of bacterial strains were investigated by exposing the strains daily to increasing sub-inhibitory concentrations of DDAC for 7 days. Following adaptation to DDAC, a 3-fold increase in the MIC values for this biocide was observed in 48% of the Escherichia coli and Listeria monocytogenes strains, and 3% of the Salmonella strains. Reduced susceptibility to other biocides was found with the most important increase in MIC for benzalkonium chloride (BC) and a commercial biocide formulation (Galox Horizon) containing DDAC and glutaraldehyde, for all species except Salmonella. Increase in antibiotic MIC values was more pronounced in Escherichia coli in terms of antibiotic numbers and of magnitude (from 4- to 32-fold increase) and, to a lesser extent, in Salmonella strains. Most of these strains had acquired resistance to ampicillin, cefotaxime, ceftazidime, chloramphenicol and ciprofloxacin. Conclusions The effects of exposure to DDAC on biocides and antibiotics susceptibilities depend upon the bacteria species. Significance and Impact of the Study Extensive use of DDAC at sub-inhibitory concentrations may lead to the development of antibiotic-resistant bacteria and may represent a public health issue This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
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