Microwave Ablation Versus Wedge Resection for Stage I Non-small Cell Lung Cancer Adjacent to the Pericardium: Propensity Score Analyses of Long-term Outcomes
| Autor: | Hao Hu, Bo Zhai, Rong Liu, Jia Chang Chi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Ablation Techniques
Male medicine.medical_specialty Lung Neoplasms Subgroup analysis 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Carcinoma Non-Small-Cell Lung Carcinoma Medicine Pericardium Humans Radiology Nuclear Medicine and imaging Progression-free survival Clinical Investigation Microwaves Propensity Score Survival rate Lung Aged Retrospective Studies Aged 80 and over business.industry Microwave ablation medicine.disease Progression-Free Survival Survival Rate medicine.anatomical_structure Treatment Outcome 030220 oncology & carcinogenesis Propensity score matching Female Radiology Cardiology and Cardiovascular Medicine business Tomography X-Ray Computed Wedge resection (lung) Follow-Up Studies |
| Zdroj: | Cardiovascular and Interventional Radiology |
| ISSN: | 1432-086X 0174-1551 |
| Popis: | Objective The present study has compared the long-term outcomes between performing wedge resection (WR) and microwave ablation (MWA) as first-line treatment of stage I non–small cell lung cancer (NSCLC) patients with tumors adjacent to the pericardium. Materials and Methods Between January 2014 and December 2018, a total of 223 consecutive patients with T1N0 NSCLC underwent first-line treatment by WR (n = 155) or image-guided lung MWA (n = 68). This study has compared the progression-free survival (PFS) and overall survival (OS) rates between the two treatments before and after propensity score matching. Subgroup analysis of these outcomes was conducted based on the distance from the pericardium. Results The median follow-up time was 47 months. Propensity matching yielded 56 pairs of patients. In the two matched groups, the PFS rates in the WR group at 3 and 5 years were 66.0% and 56.0% and 54.0% and 36.0%, respectively, in the MWA group (P = 0.029). Meanwhile, the corresponding OS rates for the WR group at 3 and 5 years were 81.0% and 72.0% and 60.0% and 55.0% in the MWA group, respectively (P = 0.031). Subgroup analysis, done according to the treatment modality, indicated that local tumor recurrence and PFS for NSCLCs that were close but not contiguous to the pericardium were different from those contiguous to the pericardium (P = 0.018 and P = 0.025, respectively). Conclusion WR provided better long-term tumor control and OS compared to MWA for stage I NSCLC adjacent to the pericardium as a first-line treatment. MWA can be considered as an alternative option for high-risk and inoperable patients, particularly for tumors that were not contiguous to the pericardium. |
| Databáze: | OpenAIRE |
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