Aloe vera gel protects liver from oxidative stress-induced damage in experimental rat model
| Autor: | Sohel Ahmed, Abdul Mannan Sikder, Shahdat Hossain, Taslima Nahar, Borhan Uddin |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Globulin Bilirubin Iron Serum albumin Pharmacology medicine.disease_cause Aloe vera Rats Sprague-Dawley chemistry.chemical_compound In vivo medicine Animals Aloe Carbon Tetrachloride Serum Albumin Transaminases biology Globulins Blood Proteins Hydrogen Peroxide Alkaline Phosphatase biology.organism_classification Rats Oxidative Stress Liver Complementary and alternative medicine chemistry Hepatoprotection Biochemistry Dietary Supplements biology.protein Alkaline phosphatase Lipid Peroxidation Plant Preparations Chemical and Drug Induced Liver Injury Gels Oxidative stress Phytotherapy |
| Zdroj: | Journal of Complementary and Integrative Medicine. 10 |
| ISSN: | 1553-3840 2194-6329 |
| DOI: | 10.1515/jcim-2012-0020 |
| Popis: | Aloe vera is a semi-tropical plant of Liliaceae family which has a wide range of applications in traditional medicine. In the present study, we sought to investigate the heptaoprotective potential of Aloe vera gel as a diet supplement. To achieve this goal, we have designed in vitro and in vivo experimental models of chemical-induced liver damage using male Sprague-Dawley rat. In the in vitro model, its effect was evaluated on Fenton's reaction-induced liver lipid peroxidation. Co-incubation with gel significantly reduced the generation of liver lipid peroxide (LPO). Next, to see the similar effect in vivo, gel was orally administered to rats once daily for 21 successive days. Following 1 hour of the last administration of gel, rats were treated with intra-peritoneal injection of CCl4. Dietary gel showed significant hepatoprotection against CCl4-induced damage as evident by restoration of liver LPO, serum transaminases, alkaline phosphatase, and total bilirubin towards near normal. The beneficial effects were pronounced with the doses used (400 and 800 mg/kg body weight). Besides, we did not observe any significant drop in serum albumin, globulin as well as total protein levels of gel-administered rats. Histopathology of the liver tissue further supported the biochemical findings confirming the hepatoprotective potential of dietary gel. |
| Databáze: | OpenAIRE |
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