Gender specific click and tone burst evoked ABR datasets from mice lacking the Cav3.2 T-type voltage-gated calcium channel
| Autor: | Anna Papazoglou, Julien Soos, Muhammad Imran Arshaad, Carola Wormuth, Andreas Lundt, Robin Seidel, Marco Weiergräber, Jürgen Hescheler, Ralf Müller, Agapios Sachinidis, Christina Henseler, Karl Broich, Dan Ehninger |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male lcsh:Medicine Audiology Monaural physiology [Evoked Potentials Auditory Brain Stem] Amplitude methods [Audiometry Evoked Response] Mice Calcium Channels T-Type 0302 clinical medicine genetics [Calcium Channels T-Type] 030212 general & internal medicine lcsh:QH301-705.5 Voltage-dependent calcium channel General Medicine Click physiology [Calcium Channels T-Type] medicine.anatomical_structure Sensorineural hearing loss Female medicine.symptom medicine.medical_specialty Hearing loss Mice Transgenic Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Sex Factors ddc:570 medicine otorhinolaryngologic diseases Auditory system Animals lcsh:Science (General) Spiral ganglion Cochlea deficiency [Calcium Channels T-Type] lcsh:R physiopathology [Hearing Loss Sensorineural] medicine.disease Cacna1h protein mouse Auditory brainstem responses Disease Models Animal Cav3.2 030104 developmental biology Auditory brainstem response lcsh:Biology (General) Calcium channel lcsh:Q1-390 |
| Zdroj: | BMC Research Notes, Vol 12, Iss 1, Pp 1-3 (2019) BMC Research Notes 12(1), 157 (2019). doi:10.1186/s13104-019-4169-4 |
| ISSN: | 1756-0500 |
| DOI: | 10.1186/s13104-019-4169-4 |
| Popis: | Objectives Voltage-gated Ca2+ channels (VGCCs) are of central relevance in regulating Ca2+ influx into living cells. The low-voltage activated (LVA) Cav3 T-type Ca2+ channels are widely distributed throughout the brain including the peripheral auditory system and ascending auditory tract. Their exact role in auditory information processing is still not fully understood. Within the LVA subgroup, Cav3.2 T-type Ca2+ channels seem to be of special importance as qPCR revealed a steady increase in Cav3.2 transcript levels over age, e.g. in the cochlea and spiral ganglion neurons (SGN). Furthermore, pharmacological studies suggested an association between Cav3.2 expression and both age-related and noise-induced hearing loss. Given the potential functional relevance of Cav3.2 VGGCs in sensorineural hearing loss, we recorded gender specific auditory evoked brainstem responses (ABRs) upon both click and tone burst presentation. Here we present auditory brainstem response (ABR) data from Cav3.2+/+, Cav3.2+/− and Cav3.2−/− mice from both genders which are of value for researchers who want to evaluate how Cav3.2 loss affects basic auditory parameters, e.g. click and tone burst based hearing thresholds, amplitude growth function and peak latencies. Data description Information presented here includes ABR data from age-matched female and male Cav3.2+/+, Cav3.2+/− and Cav3.2−/− mice and technical aspects of the auditory recording protocol. Data were recorded using a commercially available ABR setup from Tucker Davis Technologies Inc. (TDT). Raw data files (arf.-file format) were exported as txt.-files with free access for analysis. |
| Databáze: | OpenAIRE |
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