Biomodulina T May Restore Immunity in Older Adults
| Autor: | Danay Saavedra-Hernández, Gisela María Suárez-Formigo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Aging Immunosenescence medicine.medical_treatment Population Recent Thymic Emigrant 03 medical and health sciences 0302 clinical medicine Immune system Immunity medicine Humans Immunologic Factors education Aged education.field_of_study Biological Products business.industry Cuba General Medicine Immunotherapy Vaccination 030104 developmental biology Immunology Stem cell business 030215 immunology |
| Zdroj: | MEDICC review. 22(3) |
| ISSN: | 1527-3172 |
| Popis: | Worldwide, there has been a progressive demographic shift over the past 50 years resulting in a larger proportion of older adults in the general population. Aging itself is a complex biological phenomenon characterized in part by changes in the immune system known as "immunosenescence", which makes older adults more susceptible to infectious, cardiovascular and autoimmune diseases, as well as cancers. Several strategies have been proposed in an attempt to reverse immunosenescence, including use of hormones, cytokines and thymic factors. A promising drug in the search to restore the thymic microenvironment (which plays an important role in the regulation and maintenance of the immune system) in older adults is Biomodulina T, a Cuban product registered for use in patients with recurrent respiratory infections. The administration of Biomodulina T increases the number of naive T-lymphocyte, CD4-positive cells that have recently migrated from the thymus gland (recent thymic emigrants) and memory CD8-positive T lymphocytes, which have characteristics akin to stem cells (stem cell-like memory). Furthermore, the expression of programmed cell death 1 protein in CD4-positive T lymphocytes and CD4-positive T lymphocytes decreases, and the proliferative capacity of CD4-positive T lymphocytes increases, without changes in the frequency of regulatory T lymphocytes. These results suggest that the administration of Biomodulina T could be used to restore immunity in older adults and in other immunocompromised individuals, improve response to other immunotherapies in cancer patients, and increase the effi cacy of vaccinations in older adults. Its use has been approved in Cuba for immune system restoration.KEYWORDS Immunosenescence, aging, immunotherapy, immuno-modulation, antineoplastic protocols, Cuba. |
| Databáze: | OpenAIRE |
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