Treatment of Multiple Sclerosis with Methylprednisolone and Mitoxantrone Modulates the Expression of CXC Chemokine Receptors in PBMC
| Autor: | Andrzej Glabinski, Andzelika Mazurek, Pawel Wolinski, Bartosz Bielecki |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Receptors CXCR5 musculoskeletal diseases Receptors CXCR4 Chemokine Multiple Sclerosis Receptors CXCR3 Immunology Gene Expression Pharmacology CXCR3 Methylprednisolone Receptors Interleukin-8B CXCR5 Receptors Interleukin-8A Chemokine receptor medicine Humans Immunology and Allergy CXC chemokine receptors skin and connective tissue diseases Receptor Receptors CXCR Mitoxantrone Dose-Response Relationship Drug biology business.industry hemic and immune systems Middle Aged Leukocytes Mononuclear biology.protein Female business medicine.drug |
| Zdroj: | Journal of Clinical Immunology. 28:122-130 |
| ISSN: | 1573-2592 0271-9142 |
| Popis: | Chemokines and their receptors are involved in the development of multiple sclerosis (MS). Methylprednisolone (MP) and mitoxantrone (MTX) are commonly used in the treatment of MS. In this study, we analyzed the expression of chemokine receptors CXCR1, CXCR2, CXCR3, CXCR4, and CXCR5 in peripheral blood mononuclear cells (PBMC) from MS patients before and after treatment with MP or MTX. We observed a significant upregulation of expression of CXCR1 and CXCR2 in untreated MS patients. Treatment of MS with MP stimulated further increase of expression of both receptors. Therapy for MS with MTX resulted in decrease of CXCR2 expression. There was a negative correlation between the expression of CXCR1 and CXCR2 and the cumulative dose of MTX received by patients. These results suggest that CXCR1 and CXCR2 may be involved in MS pathogenesis and that treatment of this disease with MP and MTX may influence expression of those receptors. |
| Databáze: | OpenAIRE |
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