Diagnostic Application of Postmortem Cardiac Troponin I Pericardial Fluid/Serum Ratio in Sudden Cardiac Death
| Autor: | María D. Pérez-Cárceles, José A. Noguera-Velasco, Eduardo Osuna, María Del Rocío Valverde-Vázquez, Juan Pedro Hernández Del Rincón, Diana Hernández-Romero |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
cardiac troponin I Clinical Biochemistry Autopsy macromolecular substances 030204 cardiovascular system & hematology Article Sudden cardiac death 03 medical and health sciences 0302 clinical medicine Internal medicine Troponin I medicine cardiovascular diseases 030216 legal & forensic medicine Myocardial infarction Cause of death Postmortem Diagnosis lcsh:R5-920 biology business.industry Pericardial fluid medicine.disease Troponin postmortem diagnosis myocardial infarction pericardial fluid biology.protein Cardiology lcsh:Medicine (General) business serum |
| Zdroj: | Diagnostics Volume 11 Issue 4 Diagnostics, Vol 11, Iss 614, p 614 (2021) |
| ISSN: | 2075-4418 |
| DOI: | 10.3390/diagnostics11040614 |
| Popis: | In approximately 5% of unexpected deaths, establishing a conclusive diagnosis exclusively on the basis of anatomo-pathological findings in a classic autopsy is difficult. Postmortem biomarkers have been actively investigated as complementary indicators to help to reach valid conclusions about the circumstances of death. Several studies propose either the pericardial fluid or peripheral veins as a location for troponin determination, but the optimum sampling site is still a matter of debate. Our objective was to evaluate the association between the ratio of troponin values in the pericardial fluid and serum (determined postmortem) and the diagnosis of acute myocardial infarction (AMI) in the context of sudden cardiac death. We included 175 forensic cases. Two groups were established: AMI deaths (48 27.4%) and the control group (127 72.6%). The cardiac Troponin I (cTnI) values in the pericardial fluid and the troponin ratio were found to be associated with the cause of death. Univariate regression analyses showed that both age and the cTnI ratio were significantly associated with the diagnosis of AMI death. In a multivariate analysis, adjusting for confounding factors, the age and cTnI ratio were independent predictors of death from myocardial infarction. We performed a receiver operating characteristic (ROC) curve for the cTnI ratio for AMI death and selected a cut-off point. Our biomarker was found to be a valuable and highly effective tool for use in the forensic field as a complementary method to facilitate diagnosis in nonconclusive autopsies. |
| Databáze: | OpenAIRE |
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