Centromeric chromatin and the pathway that drives its propagation

Autor:	Ben E. Black, Samantha J. Falk
Rok vydání:	2012
Předmět:	Genetics Cell division Kinetochore Biophysics Locus (genetics) Computational biology Biology Biochemistry Article Chromatin Histone H3 Structural Biology Centromere Repeated sequence Molecular Biology Epigenesis
Zdroj:	Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1819:313-321
ISSN:	1874-9399
DOI:	10.1016/j.bbagrm.2011.11.002
Popis:	The centromere is the locus that directs chromosomal inheritance at cell division. While centromeres in diverse eukaryotes are commonly found at sites of repetitive DNA, their location is epigenetically specified. The histone H3 variant CENP-A is the prime candidate for epigenetically marking the centromere, and recent work has uncovered several additional proteins that play key roles in centromere assembly and maintenance. We describe advances in the identification and characterization of proteins that form the centromere, and focus on recent findings that have advanced our understanding of the assembly of functional centromeric chromatin. This article is part of a Special Issue entitled: Histone chaperones and chromatin assembly.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9c1734dad3fe25c98fbf4140bcc81cd https://doi.org/10.1016/j.bbagrm.2011.11.002 Zobrazit plný text záznamu Full Text from ScienceDirect