Interval hypoxic training improves autonomic cardiovascular and respiratory control in patients with mild chronic obstructive pulmonary disease
| Autor: | Luciano Bernardi, Hannes Gatterer, Armin Linser, Igor Ehrenbourg, Gaia Casucci, Martin Faulhaber, Martin Burtscher, Guenter Ott, Thomas Haider, Elena Tkatchouk, Tobias Linser |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology Baroreflex Autonomic Nervous System Breathing Exercises law.invention Pulmonary Disease Chronic Obstructive Double-Blind Method Randomized controlled trial law Internal medicine Internal Medicine medicine Humans In patient Hypoxia Intermittent hypoxic training COPD business.industry Respiration Respiratory disease Middle Aged Hypoxia (medical) medicine.disease Adaptation Physiological respiratory tract diseases Surgery Autonomic nervous system Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Hypertension. 27:1648-1654 |
| ISSN: | 0263-6352 |
| DOI: | 10.1097/hjh.0b013e32832c0018 |
| Popis: | Chronic obstructive pulmonary disease (COPD) is associated with cardiac autonomic nervous system dysregulation. This study evaluates the effects of interval hypoxic training on cardiovascular and respiratory control in patients with mild COPD.In 18 eucapnic normoxic mild COPD patients (age 51.7 +/- 2.4 years, mean +/- SEM), randomly assigned to either training or placebo group, and 14 age-matched healthy controls (47.7 +/- 2.8 years), we monitored end-tidal carbon dioxide, airway flow, arterial oxygen saturation, electrocardiogram, and continuous noninvasive blood pressure at rest, during progressive hypercapnic hyperoxia and isocapnic hypoxia to compare baroreflex sensitivity to hypoxia and hypercapnia before and after 3 weeks of hypoxic training. In double-blind fashion, both groups received 15 sessions of passive intermittent hypoxia (training group) or normoxia (placebo group). For the hypoxia group, each session consisted of three to five hypoxic (15-12% oxygen) periods (3-5 min) with 3-min normoxic intervals. The placebo group inhaled normoxic air.Before training, COPD patients showed depressed baroreflex sensitivity, as compared with healthy individuals, without evident chemoreflex abnormalities. After training, in contrast to placebo group, the training group showed increased (P0.05) baroreflex sensitivity up to normal levels and selectively increased hypercapnic ventilatory response (P0.05), without changes in hypoxic ventilatory response.Eucapnic normoxic mild COPD patients already showed signs of cardiovascular autonomic abnormalities at baseline, which normalized with hypoxic training. If confirmed in more severe patients, interval hypoxic training may be a therapeutic strategy to rebalance early autonomic dysfunction in COPD patients. |
| Databáze: | OpenAIRE |
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