Transient-State Kinetic Analysis of the RNA Polymerase II Nucleotide Incorporation Mechanism

Autor:	Zachariah I. Carter, Ruth Q. Jacobs, David A. Schneider, Aaron L. Lucius
Rok vydání:	2022
Předmět:	Biochemistry
Zdroj:	Biochemistry. 62(1)
ISSN:	1520-4995
Popis:	Eukaryotic RNA polymerase II (Pol II) is an essential enzyme that lies at the core of eukaryotic biology. Due to its pivotal role in gene expression, Pol II has been subjected to a substantial number of investigations. We aim to further our understanding of Pol II nucleotide incorporation by utilizing transient-state kinetic techniques to examine Pol II single nucleotide addition on the millisecond time scale. We analyzed
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9bd7e187573b084aad2f3d4e5fbafd8 https://pubmed.ncbi.nlm.nih.gov/36525636 Zobrazit plný text záznamu