High diversity of MIC genes in non-human primates
| Autor: | Ronald E. Bontrop, Antoine Blancher, Raphael Carapito, Alice Meyer, Erin J. Adams, Louise Ott, Seiamak Bahram, Philippe Georgel, Mirjana Radosavljevic, Peter Parham |
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| Rok vydání: | 2014 |
| Předmět: |
Pan troglodytes
Molecular Sequence Data Immunology Genes MHC Class I Biology Exon Phylogenetics Sequence Homology Nucleic Acid MHC class I Genetics Animals Humans Amino Acid Sequence Allele Gene Peptide sequence Phylogeny Gorilla gorilla Polymorphism Genetic Multiple sequence alignment Base Sequence Sequence Homology Amino Acid Phylogenetic tree Macaca fascicularis biology.protein |
| Zdroj: | Immunogenetics. 66:581-587 |
| ISSN: | 1432-1211 0093-7711 |
| DOI: | 10.1007/s00251-014-0791-4 |
| Popis: | The human MHC class I (MHC-I) chain-related genes A and B (MICA and MICB) encode stress-induced glycoproteins, ligands for the activating receptor NKG2D. They display an unusually high degree of polymorphism, next only to that of classical MHC-I. The functional relevance and selective pressure behind this peculiar polymorphism, which is quite distinct from that of classical MHC-I, remain largely unknown. This study increases the repertoire of allelic sequences determined for the MIC genes of non-human primates. Sequencing (mainly exons 2, 3, 4, 5) MIC genes of 72 Macaca fascicularis (Mafa), 63 Pan troglodytes (Patr), and 18 Gorilla gorilla (Gogo) individuals led to the identification of 35, 14, and 3 new alleles, respectively. Additionally, we confirm the existence of three independent MIC genes in M. fascicularis, i.e., Mafa-MICA, Mafa-MICB, and Mafa-MICB/A, the latter being a hybrid of Mafa-MICB and Mafa-MICA. By multiple sequence alignment and phylogenetic analysis, we further demonstrate that the present day MIC genes most likely derive from a single human MICB-like ancestral gene. |
| Databáze: | OpenAIRE |
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