Engineering Selectively Targeting Antimicrobial Peptides
| Autor: | James A. Van Deventer, Kyongbum Lee, Ming Lei, Arul Jayaraman |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Bacteria Chemistry High-throughput screening 030106 microbiology Antimicrobial peptides Biomedical Engineering Medicine (miscellaneous) Computational biology Protein Engineering Cell selectivity Article Anti-Bacterial Agents 03 medical and health sciences Functional diversity 030104 developmental biology Humans Antimicrobial Peptides |
| Zdroj: | Annu Rev Biomed Eng |
| ISSN: | 1545-4274 1523-9829 |
| DOI: | 10.1146/annurev-bioeng-010220-095711 |
| Popis: | The rise of antibiotic-resistant strains of bacterial pathogens has necessitated the development of new therapeutics. Antimicrobial peptides (AMPs) are a class of compounds with potentially attractive therapeutic properties, including the ability to target specific groups of bacteria. In nature, AMPs exhibit remarkable structural and functional diversity, which may be further enhanced through genetic engineering, high-throughput screening, and chemical modification strategies. In this review, we discuss the molecular mechanisms underlying AMP selectivity and highlight recent computational and experimental efforts to design selectively targeting AMPs. While there has been an extensive effort to find broadly active and highly potent AMPs, it remains challenging to design targeting peptides to discriminate between different bacteria on the basis of physicochemical properties. We also review approaches for measuring AMP activity, point out the challenges faced in assaying for selectivity, and discuss the potential for increasing AMP diversity through chemical modifications. |
| Databáze: | OpenAIRE |
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