Deciphering the Peculiar Behavior of β-Lapachone in Lipid Monolayers and Bilayers
| Autor: | Patrick Trouillas, David Chapron, Véronique Rosilio, Florent Di Meo, Benjamin Chantemargue, Xiao Wu, Claudie Bourgaux |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Liposome
Surface Properties β lapachone Chemistry Lipid Bilayers digestive oral and skin physiology 02 engineering and technology Surfaces and Interfaces 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Anticancer drug Combinatorial chemistry 0104 chemical sciences Monolayer Phosphatidylcholines Electrochemistry General Materials Science Particle Size Solubility 0210 nano-technology Spectroscopy Naphthoquinones |
| Zdroj: | Langmuir. 35:14603-14615 |
| ISSN: | 1520-5827 0743-7463 |
| Popis: | β-Lapachone (β-Lap) is a promising anticancer drug whose applications have been limited so far because of its poor solubility and stability. Its encapsulation in liposomes has been proposed to overcome these issues. However, surface pressure measurements show that β-Lap exhibits atypical interfacial behavior when mixed with lipids. Although the drug does not seem to be retained in lipid monolayers as deduced from the π |
| Databáze: | OpenAIRE |
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