beta-Alkylthio indolyl carbinols: potent nonsteroidal antiandrogens with oral efficacy in a prostate cancer model

Autor:	Zhihua Sui, Vernon C. Alford, Olivia Linton, Xuqing Zhang, Ronald K. Russell, George F. Allan, Muh-Tsann Lai, James C. Lanter, Scott G. Lundeen, Kenneth M. Wells, James J. Fiordeliso
Rok vydání:	2006
Předmět:	Male medicine.medical_specialty Indoles Antiandrogens medicine.drug_class Chemistry Pharmaceutical Clinical Biochemistry Pharmaceutical Science Administration Oral Antineoplastic Agents Antiandrogen Biochemistry chemistry.chemical_compound Prostate cancer Mice Structure-Activity Relationship Oral administration Prostate In vivo Internal medicine Drug Discovery medicine Animals Molecular Biology Chemistry Methanol Organic Chemistry Prostatic Neoplasms Androgen Antagonists medicine.disease In vitro Rats Disease Models Animal Endocrinology medicine.anatomical_structure Drug Design Cancer research Molecular Medicine Bioisostere Drug Screening Assays Antitumor Neoplasm Transplantation
Zdroj:	Bioorganicmedicinal chemistry letters. 17(9)
ISSN:	0960-894X
Popis:	Through an in vivo screening model, we developed the in vivo SAR of beta-alkylthio indolyl carbinols. Through these efforts we identified a compound with potent oral in vivo efficacy in both immature and mature rat prostate weight reduction models and in a murine xenograft prostate cancer model.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b775788f1d9d70864c1209376a8b72 https://pubmed.ncbi.nlm.nih.gov/17337185 Zobrazit plný text záznamu Full Text from ScienceDirect