Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology
| Autor: | Jennifer K. Litton, Kenneth Offit, Christine Laronga, Matthew B. Yurgelun, Leigha Senter-Jamieson, Kristen M. Shannon, Ahmed Elkhanany, Beth Y. Karlan, Seema A. Khan, Susan M. Domchek, Kari B. Wisinski, Patricia I. Dickson, Gwen Reiser, Holly J. Pederson, Catherine Klein, Barbara S. Norquist, Mary B. Daly, Allison W. Kurian, Wendy Kohlmann, Carolyn S. Menendez, Jeffrey N. Weitzel, Mary A. Dwyer, Mollie L. Hutton, Susan Darlow, Kala Visvanathan, Sofia D. Merajver, Rebecca Shatsky, Myra J. Wick, Michael Goggins, Saundra S. Buys, Michael Berry, Susan Hatters Friedman, Julie S. Mak, Tuya Pal |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Oncology medicine.medical_specialty Colorectal cancer Genetic counseling Genes BRCA2 Genes BRCA1 Breast Neoplasms Genetic Counseling Cancer syndrome Prostate cancer Internal medicine Pancreatic cancer medicine Humans Genetic Predisposition to Disease Genetic Testing skin and connective tissue diseases Genetic testing Ovarian Neoplasms medicine.diagnostic_test business.industry Cancer medicine.disease Pancreatic Neoplasms Mutation Female Ovarian cancer business |
| Zdroj: | Journal of the National Comprehensive Cancer Network. 19:77-102 |
| ISSN: | 1540-1413 1540-1405 |
| Popis: | The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic focus primarily on assessment of pathogenic or likely pathogenic variants associated with increased risk of breast, ovarian, and pancreatic cancer and recommended approaches to genetic testing/counseling and management strategies in individuals with these pathogenic or likely pathogenic variants. This manuscript focuses on cancer risk and risk management for BRCA-related breast/ovarian cancer syndrome and Li-Fraumeni syndrome. Carriers of a BRCA1/2 pathogenic or likely pathogenic variant have an excessive risk for both breast and ovarian cancer that warrants consideration of more intensive screening and preventive strategies. There is also evidence that risks of prostate cancer and pancreatic cancer are elevated in these carriers. Li-Fraumeni syndrome is a highly penetrant cancer syndrome associated with a high lifetime risk for cancer, including soft tissue sarcomas, osteosarcomas, premenopausal breast cancer, colon cancer, gastric cancer, adrenocortical carcinoma, and brain tumors. |
| Databáze: | OpenAIRE |
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