Preparation of N-acetyl-para-aminophenol via a flow route of a clean amination and acylation of p-nitrophenol catalyzing by core-shell Cu2O@CeO2
| Autor: | Xiaojing Wang, Fenghua Bai, Yuxuan Ma, Yue Li, Yuanyuan Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
General Chemical Engineering
Selective conversion 02 engineering and technology 010402 general chemistry 01 natural sciences Redox Catalysis Acylation lcsh:Chemistry Nitrophenol chemistry.chemical_compound Reactivity (chemistry) P-nitrophenol Amination Chemistry General Chemistry 021001 nanoscience & nanotechnology Core-shell Cu2O@CeO2 Combinatorial chemistry 0104 chemical sciences Paracetamol lcsh:QD1-999 Yield (chemistry) P-anomiphenol 0210 nano-technology Selectivity |
| Zdroj: | Arabian Journal of Chemistry, Vol 13, Iss 12, Pp 8613-8625 (2020) |
| ISSN: | 1878-5352 |
| Popis: | The selectivity and reactivity to converse series nitroaromatic into aminobenzenes are especially significant, which play a vital role in synthesizing required drugs or other fine chemicals. Herein, p-nitrophenol (p-NP) has been completely conversed into p-anomiphenol (p-AP) with a high activity factor k (0.033 s−1·mg−1) and reusability by core-shell Cu2O@CeO2 catalyst. N-acetyl-para-aminophenol (paracetamal, APAP) as a model drug was further synthesized via a flow route proceeded in two steps including p-NP reduction and subsequently p-AP acylation with self-constructing device. The yield of the paracetamal is up to 85% with a highly purity. The mechanism investigation justifies the rich-electron centers and cation defects generated from the redox coupled Cu+→Cu0 with Ce3+→Ce4+ will steer selective conversion of p-NP to p-AP, a rate-determining step in the production of APAP. The present results could visualize a highly selective catalyst and a new synthesis route for pharmaceuticals such as paracetamal by using nitroaromatic compounds as the raw materials with environment-friendly, low-cost, easy-manipulation, high-efficiency and high purity. |
| Databáze: | OpenAIRE |
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