Action of gastrointestinal hormones on the myoelectric activity of the sphincter of Oddi in living rabbit
| Autor: | H. Castello, M.A. Devaux, Delecourt P, M. Nacchiero, J.P. Amoros, L. Gaeta, Sarles Jc, R. Awad |
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| Rok vydání: | 1981 |
| Předmět: |
Male
Ampulla of Vater medicine.medical_specialty Physiology Clinical Biochemistry Tachyphylaxis digestive system Biochemistry Glucagon Sincalide Secretin Gastrointestinal Hormones Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology Internal medicine Gastrins Sphincter of Oddi medicine Animals Humans Gastrin Dose-Response Relationship Drug Electromyography business.industry digestive oral and skin physiology Bombesin Electrophysiology Gastrointestinal hormone chemistry Rabbits Cholecystokinin business Ceruletide hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Regulatory Peptides. 2:113-124 |
| ISSN: | 0167-0115 |
| DOI: | 10.1016/0167-0115(81)90005-7 |
| Popis: | The aim of this work was to compare the action of gastrointestinal (GI) hormones on the myoelectrical activity of the sphincter of Oddi. Using an experimental design previously described, we studied the electrical activity of the sphincter of Oddi and compared the percentage variation in the number of spikes before and after injection of hormones. Increasing doses of the following hormones were injected i.v. at random: CCK, OP-CCK, caerulein, bombesin, gastrin, secretin and glucagon. CCK and caerulein (as previously found), and also bombesin, OP-CCK and gastrin increased the spikes activity of the sphincter of Oddi. Secretin had no effect and glucagon decreased this activity. There was no tachyphylaxis, but a good dose-effect relationship for each hormone. Compared on a molar basis caerulein is 8 times more effective than CCK and OP-CCK which in turn are more potent than bombesin. Gastrin acts only at pharmacological doses. |
| Databáze: | OpenAIRE |
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