The Human Circadian Pacemaker Can See by the Dawn's Early Light
| Autor: | Michael Terman, Konstantin V. Danilenko, Kurt Kräuchi, Anna Wirz-Justice, Jakob M. Weber |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Physiology Photoperiod Period (gene) Biology Body Temperature Melatonin 03 medical and health sciences 0302 clinical medicine Rhythm Physiology (medical) Internal medicine medicine Zeitgeber Humans Circadian rhythm Saliva Lighting Phase response curve photoperiodism Computers Rectum Dose-Response Relationship Radiation Circadian Rhythm 030104 developmental biology Endocrinology Sunlight sense organs Dawn simulation Algorithms 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Biological Rhythms. 15:437-446 |
| ISSN: | 1552-4531 0748-7304 |
| DOI: | 10.1177/074873000129001521 |
| Popis: | The authors' previous experiments have shown that dawn simulation at low light intensities can phase advance the circadian rhythm of melatonin in humans. The aim of this study was to compare the effect of repeated dawn signals on the phase position of circadian rhythms in healthy participants kept under controlled light conditions. Nine men participated in two 9-day laboratory sessions under an LD cycle 17.5:6.5 h, < 30:0 lux, receiving 6 consecutive daily dawn (average illuminance 155 lux) or control light (0.1 lux) signals from 0600 to 0730 h (crossover, random-order design). Two modified constant routine protocols before and after the light stimuli measured salivary melatonin (dim light melatonin onset DLMOn and offset DLMOff) and rectal temperature rhythms (midrange crossing time [MRCT]). Compared with initial values, participants significantly phase delayed after 6 days under control light conditions (at least –42 min DLMOn, –54 min DLMOff, –41 min MRCT) in spite of constant bedtimes. This delay was not observed with dawn signals (+10 min DLMOn, +2 min DLMOff, 0 min MRCT). Given that the endogenous circadian period of the human circadian pacemaker is slightly longer than 24 h, the findings suggest that a naturalistic dawn signal is sufficient to forestall this natural delay drift. Zeitgeber transduction and circadian system response are hypothesized to be tuned to the time-rate-of-change of naturalistic twilight signals. |
| Databáze: | OpenAIRE |
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