Histopathology of the donor gallbladder removed at orthotopic liver transplantation: correlation with graft function
| Autor: | Shashi Dwarakanath, Charles F. Arkin, C. Wright Pinson, Roger L. Jenkins, Urmila Khettry |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Reoperation
medicine.medical_specialty Necrosis Orthotopic liver transplantation Hemorrhage Gastroenterology Pathology and Forensic Medicine Lesion Liver Function Tests Internal medicine medicine Humans Transplantation Homologous Mucous Membrane medicine.diagnostic_test business.industry Gallbladder Graft Survival Prognosis Tissue Donors Liver Transplantation Transplantation medicine.anatomical_structure Liver Histopathology Liver function medicine.symptom Liver function tests business |
| Zdroj: | Human pathology. 22(5) |
| ISSN: | 0046-8177 |
| Popis: | The histopathology of 50 consecutive donor gallbladders removed during orthotopic liver transplantation was reviewed and correlated with graft function. Multiple sections of the gallbladders were examined for the presence of mucosal congestion, hemorrhage, and necrosis, without prior knowledge of the clinical outcome. Each pathologic feature was graded as absent (0), involving less than 10% (1+), 10% to 50% (2+), or more than 50% (3+) of the histologically examined mucosa. Graft function was determined by two transplant surgeons, a poor diagnosis being worsening of liver function tests associated with declining mental status and resulting in immediate retransplantation or early postoperative death; all others were categorized as good. Of 39 patients with good graft function, 18 had normal donor gallbladders, 11 had congestion only, and 10 had hemorrhage and/or necrosis. Of 11 patients with poor graft function, eight had hemorrhage and/or necrosis (2+ in seven), three had congestion only, and none had a normal gallbladder mucosa. Congestion alone was found to be a poor predictor of graft damage. Presence of any grade of hemorrhage and/or necrosis in donor gallbladders as related to poor liver graft function had a sensitivity of 73%, a specificity of 74%, a positive predictive value of 44%, and a negative predictive value of 91%. When hemorrhage and/or necrosis of 2+ severity was separately grouped and correlated with poor graft function, the specificity rose to 97% and the positive predictive value to 88%, and the negative predictive value was similar at 90%. We conclude that donor gallbladders often show mucosal abnormalities consisting of varying degrees of congestion, hemorrhage, and necrosis. The finding of hemorrhage and/or necrosis affecting more than 10% of the mucosa appears to be a specific lesion of ischemic damage that correlates highly with poor liver graft function. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|