Synthesis and biological evaluation of new 4H-pyrano[2,3-b]quinoline derivatives that block acetylcholinesterase and cell calcium signals, and cause neuroprotection against calcium overload and free radicals

Autor:	Antonio G. García, Mercedes Villarroya, Rafael León, Manuela G. López, José Marco-Contelles
Rok vydání:	2006
Předmět:	Magnetic Resonance Spectroscopy Free Radicals Aché Stereochemistry Chromaffin Cells Radical Drug Evaluation Preclinical chemistry.chemical_element Calcium Chemical synthesis Neuroprotection Mass Spectrometry Cell Line chemistry.chemical_compound Drug Discovery Animals Potency Calcium Signaling Calcium overload Pyrans Biological evaluation Pharmacology chemistry.chemical_classification L-Lactate Dehydrogenase biology Chemistry Organic Chemistry Quinoline Biological activity General Medicine Acetylcholinesterase language.human_language Neuroprotective Agents Enzyme Adrenal Medulla Enzyme inhibitor Quinolines language biology.protein Cattle Cholinesterase Inhibitors
Zdroj:	European Journal of Medicinal Chemistry. 41:1464-1469
ISSN:	0223-5234
DOI:	10.1016/j.ejmech.2006.06.016
Popis:	The synthesis and biological evaluation of ethyl 5-amino-4-(3-pyridyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrano[2,3-b]quinoline-3-carboxylates (9-11) is described. We have found that these compounds inhibit AChE with a mild potency, mitigates the [Ca(2+)](c) triggered by high K(+), and cause neuroprotection against Ca(2+) overloading and free radical-induced neuronal death.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b225a35c30928b3d8511707873723a https://doi.org/10.1016/j.ejmech.2006.06.016 Zobrazit plný text záznamu Full Text from ScienceDirect