Antimicrobial and biological effects of polyaniline/polyvinylpyrrolidone nanocomposites loaded with silver nanospheres/triangles
| Autor: | Andreja Leskovac, Slađana Davidović, Una Stamenović, Milovan Stoiljković, Sandra Petrović, Vesna Vodnik |
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| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Nanocomposite Polyvinylpyrrolidone Precipitation (chemistry) 02 engineering and technology General Chemistry Polymer 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 6. Clean water Catalysis Silver nanoparticle 0104 chemical sciences chemistry.chemical_compound Aniline chemistry Polymerization Polyaniline Materials Chemistry medicine 0210 nano-technology Nuclear chemistry medicine.drug |
| Zdroj: | New Journal of Chemistry |
| ISSN: | 1369-9261 1144-0546 |
| Popis: | Two silver-polyaniline/polyvinylpyrrolidone (Ag-PANI/PVP) nanocomposites were prepared using in situ integration of silver nanoparticles (AgNPs) during oxidative aniline polymerization, accelerated by the presence of PVP, which as well minimized the risk of particle agglomeration and macroscopic precipitation. Both nanocomposites have similar silver content (similar to 44 wt% Ag) but different morphological features of AgNPs (spheres/triangles) and polymers (granular/wrinkling pattern). Several spectroscopic, macroscopic, and analytical techniques, microscopy, and surface analysis methods have been used to analyze their physical and chemical properties. Investigation of their antimicrobial potential and possible application as an effective weapon against indicator microbial strains, E. coli, S. aureus, and C. albicans, has shown inhibition of microbial growth by more than 90%, even at low composite concentrations (5 ppm) and short contact time (4 h). A biosafety assessment of Ag-PANI/PVP that comprised testing the genotoxicity and redox modulating activity was performed using human peripheral blood cells as a model system. The obtained results have shown that the investigated Ag-PANI/PVP exhibited significant prooxidant and cytostatic effects (p lt 0.05) with no apparent potential to induce DNA damage. Although precautions should be taken to protect human health, the significant antimicrobial efficiency of Ag-PANI/PVP makes it suitable for further studies and applications in non-medical areas, such as wastewater treatment. |
| Databáze: | OpenAIRE |
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