Comparative effectiveness of nonpurpuragenic 595-nm pulsed dye laser and microsecond 1064-nm neodymium:yttrium-aluminum-garnet laser for treatment of diffuse facial erythema: A double-blind randomized controlled trial
| Autor: | Simon Yoo, Emir Veledar, Nataya Voravutinon, Emily Poon, Dennis Whiting, Melanie Warycha, Murad Alam, Dennis P. West, Michael Nodzenski |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Lasers Dye Pain chemistry.chemical_element Lasers Solid-State Dermatology Neodymium law.invention Double blind Young Adult Double-Blind Method stomatognathic system Randomized controlled trial law Photography Humans Medicine Facial erythema Pain Measurement Dye laser business.industry Neodymium-yttrium-aluminum-garnet laser Patient Preference Middle Aged Laser Microsecond chemistry Erythema Spectrophotometry Female sense organs business Nuclear medicine Facial Dermatoses |
| Zdroj: | Journal of the American Academy of Dermatology. 69:438-443 |
| ISSN: | 0190-9622 |
| DOI: | 10.1016/j.jaad.2013.04.015 |
| Popis: | Background Facial erythema is a common symptom that responds to vascular laser treatment, but there are few comparative studies. Objective We sought to compare the effectiveness of microsecond 1064-nm neodymium:yttrium-aluminum-garnet (Nd:YAG) laser with nonpurpuragenic 595-nm pulsed dye laser (PDL) for diffuse facial erythema. Methods This was a split-face, double-blind randomized controlled trial. Bilateral cheeks received 4 treatments each at one month intervals with PDL or Nd:YAG. Spectrophotometer measurements, digital photographs, pain scores, and patient preferences were recorded. Results Sixteen patients enrolled and 2 dropped out. Fourteen patients, all skin types I to III, 57% women, mean age 42 years, completed the study and were analyzed. Spectrophotometer readings changed after both PDL (8.9%) and Nd:YAG (2.5%), but varied by treatment type, with PDL reducing facial redness 6.4% more from baseline than Nd:YAG ( P = .0199; 95% confidence interval −11.6 to −1.2). Pain varied ( P = .0028), with Nd:YAG associated with less pain, at 3.07, than PDL at 3.87. Subjects rated redness as improved by 52% as a result of PDL, and 34% as a result of Nd:YAG ( P = .031; 95% confidence interval −34.6 to −1.94). No serious adverse events were observed. Limitations Lasers settings are not standardized across devices. Conclusion Facial erythema is safely and effectively treated with PDL and Nd:YAG. Nonpupuragenic PDL may be more effective for lighter-skinned patients, but microsecond Nd:YAG may be less painful. |
| Databáze: | OpenAIRE |
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