The effect of probucol and vitamin E treatment on the oxidation of low-density lipoprotein and forearm vascular responses in humans
| Autor: | G D Johnston, Geraldine M. Brennan, Jane McEneny, I. F. W. McDOWELL, I. Bruce, Ian S. Young, E. R. Trimble, D.P. Nicholls, Gary E. McVeigh |
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| Předmět: |
Vitamin
Adult Male medicine.medical_specialty Simvastatin Antioxidant medicine.medical_treatment Clinical Biochemistry Probucol Hyperlipidemias Biochemistry Drug Administration Schedule chemistry.chemical_compound Double-Blind Method Internal medicine medicine Humans Vitamin E Lovastatin Hypolipidemic Agents biology Cholesterol General Medicine Cholesterol LDL Middle Aged Forearm Endocrinology chemistry Regional Blood Flow Low-density lipoprotein HMG-CoA reductase biology.protein lipids (amino acids peptides and proteins) Drug Therapy Combination Female Oxidation-Reduction medicine.drug Lipoprotein |
| Zdroj: | Scopus-Elsevier |
| Popis: | This study investigates the hypothesis that lipid soluble antioxidants may increase the resistance of low-density lipoprotein (LDL) to oxidation and also enhance vascular endothelial responses in humans. In a double-blind parallel group study, 24 hypercholesterolaemic patients, already on treatment with simvastatin (20 mg day-'), were randomized to supplementary treatment with probucol (500 mg bd), vitamin E (400IU daily) or placebo for 8 weeks. Mean serum cholesterol before antioxidant treatment was 7.00mmoll-'. Resistance of LDL to oxidation by copper was increased by 830% in the probucol group and by 30% in the vitamin E group. However, thiobar- bituric acid reacting substances in whole serum were not altered by either antioxidant. Probucol lowered HDL- and LDL-cholesterol levels and increased the QT inter- val. Forearm vascular responses, as measured by venous occlusion plethysmography, to acetylcholine, glyceryl trinitrate and NG-monomethyl-L-arginine, were not significantly changed by antioxidant treatment. Probu- col has a major, and vitamin E a minor, effect on LDL resistance to oxidation but neither compound appears to alter forearm vascular responses in vivo. |
| Databáze: | OpenAIRE |
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