Polyurethane biocidal polymeric surface modifiers
| Autor: | Umit G. Makal, Dennis E. Ohman, Kenneth J. Wynne, Lynn F. Wood |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Staphylococcus aureus
Biocide Materials science Surface Properties Polyurethanes Biophysics Hypochlorite Bioengineering Microbial Sensitivity Tests Biomaterials Contact angle chemistry.chemical_compound Anti-Infective Agents Amide Escherichia coli Nanotechnology Organic chemistry Polymeric surface Polyurethane Hydantoins Fluorine chemistry Mechanics of Materials Pseudomonas aeruginosa Ceramics and Composites Surface modification Isophorone diisocyanate Nuclear chemistry |
| Zdroj: | Biomaterials. 27:1316-1326 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/j.biomaterials.2005.08.038 |
| Popis: | Polyurethanes (PUs) with soft blocks containing semifluorinated (-CH2OCH2CF3) and 5,5-dimethylhydantoin pendant groups were prepared and employed (2 wt%) as biocidal polymeric surface modifiers (PSMs) for a conventional PU coating comprised of an isophorone diisocyanate/1,4-butanediol-derived hard block (50%) and poly(tetramethylene oxide) soft block. Surface enrichment of the PSM was verified by dynamic contact angle measurements. The PSM modified PU was activated by converting near-surface amide groups to chloramide with 3wt% hypochlorite. The conversion of near-surface amide to chloramide is reflected in somewhat increased hydrophobic character for the antimicrobial chloramide functionalized surfaces. Biocidal activity against both Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa, and Escherichia coli) bacteria was demonstrated by using a modified version of American Association of Textile Chemists and Colorists (AATCC-100) test. By changing the PSM concentration it was found that only 1.6 wt% PSM (0.66 wt% biocide, 5,5-dimethylhydantoin) in a conventional PU affected complete kill of P. aeruginosa in 15 min by using this biocidal testing protocol. |
| Databáze: | OpenAIRE |
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