Emergence of meningococci with reduced susceptibility to third-generation cephalosporins
| Autor: | Eva Hong, Ala-Eddine Deghmane, Muhamed-Kheir Taha |
|---|---|
| Přispěvatelé: | Centre National de Référence des Méningocoques et Haemophilus influenzae - National Reference Center Meningococci and Haemophilus influenzae (CNR), Institut Pasteur [Paris] (IP), This work was supported by the Institut Pasteur and an ANR (Agence National de la Recherche) grant number ANR-14-CE14-0003, ANR-14-CE14-0003,ORBiMP,Déjouer la résistance aux beta-lactamines des méningocoques et pneumocoques(2014), Institut Pasteur [Paris] |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Antibiotic resistance Cephalosporin Antibiotics cephalosporin MESH: Anti-Bacterial Agents/pharmacology Neisseria meningitidis medicine.disease_cause MESH: Genotype Pharmacology (medical) MESH: Microbial Sensitivity Tests MESH: Cephalosporins/pharmacology Cephalosporin Resistance meningococci 3. Good health Anti-Bacterial Agents Infectious Diseases MESH: Multilocus Sequence Typing MESH: Neisseria meningitidis/genetics gonococci France MESH: Genes Bacterial medicine.drug Microbiology (medical) Sexual transmission Genotype medicine.drug_class 030106 microbiology MESH: Cephalosporin Resistance MESH: Meningococcal Infections/microbiology Microbial Sensitivity Tests Biology Microbiology 03 medical and health sciences medicine Humans Urethritis Allele Pharmacology MESH: Humans medicine.disease [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology Cephalosporins Penicillin MESH: France Meningococcal Infections 030104 developmental biology MESH: Neisseria meningitidis/isolation & purification Genes Bacterial Neisseria gonorrhoeae Multilocus sequence typing MESH: Neisseria meningitidis/classification MESH: Neisseria meningitidis/drug effects Multilocus Sequence Typing |
| Zdroj: | Journal of Antimicrobial Chemotherapy Journal of Antimicrobial Chemotherapy, 2017, 72 (1), pp.95-98. ⟨10.1093/jac/dkw400⟩ Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2017, 72 (1), pp.95-98. ⟨10.1093/jac/dkw400⟩ |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/dkw400⟩ |
| Popis: | International audience; OBJECTIVES:Reduced susceptibility to penicillin G in Neisseria meningitidis is mainly due to alterations in PBP2 encoded by the penA gene. However, this phenotype was not associated with reduced susceptibility to third-generation cephalosporins (C3Gs). We aimed to study the emergence of meningococci with reduced susceptibility to C3Gs (MIC >0.06 mg/L) in France since 2012.METHODS:Invasive meningococcal isolates were typed by MLST and penA sequencing and their antibiotic susceptibility was tested.RESULTS:Isolates with reduced susceptibility to C3Gs represented 2% of all invasive isolates from 2012-15, but were absent before. They harboured a new penA allele, penA327, that was also detected in isolates from urethritis cases and in gonococci.CONCLUSIONS:Surveillance of these isolates should be enhanced as they may jeopardize the use of C3Gs in the management of invasive meningococcal disease. |
| Databáze: | OpenAIRE |
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