The awareness, efficacy, safety, and time in therapeutic range of warfarin in the Turkish population: WARFARIN-TR
| Autor: | Ahmet, Çelik, Servet, İzci, Mehmet Ali, Kobat, Ahmet Hakan, Ateş, Abdülkadir, Çakmak, Yasin, Çakıllı, Mehmet Birhan, Yılmaz, Mehdi, Zoghi, Didem, Ovla |
|---|---|
| Přispěvatelé: | Ege Üniversitesi, [Celik, Ahmet] Mersin Univ, Fac Med, Dept Cardiol, Mersin, Turkey -- [Izci, Servet] Kosuyolu Educ & Res Hosp, Dept Cardiol, Istanbul, Turkey -- [Kobat, Mehmet Ali] Firat Univ, Fac Med, Dept Cardiol, Elazig, Turkey -- [Ates, Ahmet Hakan] Samsun Educ & Res Hosp, Dept Cardiol, Samsun, Turkey -- [Cakmak, Abdulkadir] Amasya Univ, Fac Med, Dept Cardiol, Amasya, Turkey -- [Cakilli, Yasin] Siyami Ersek Educ & Res Hosp, Dept Cardiol, Istanbul, Turkey -- [Yilmaz, Mehmet Birhan] Cumhuriyet Univ, Fac Med, Dept Cardiol, Sivas, Turkey -- [Zoghi, Mehdi] Ege Univ, Dept Cardiol, Fac Med, Izmir, Turkey, Celikcan, Havva Didem -- 0000-0003-4868-861X, Altay, Servet -- 0000-0001-7112-3970, YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628, YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628, Ozbek, Kerem -- 0000-0002-0603-3976, Kis, Mehmet -- 0000-0003-0775-8992, Koksal Cakirlar, Fatma -- 0000-0003-4279-434X |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Turkish population endocrine system business.industry Warfarin Atrial fibrillation medicine.disease Coronary artery disease warfarin time in therapeutic range INR self-monitoring Heart failure Internal medicine Concomitant medicine Physical therapy cardiovascular diseases Cardiology and Cardiovascular Medicine Prospective cohort study business medicine.drug Original Investigation |
| Zdroj: | Anatolian Journal of Cardiology |
| ISSN: | 2149-2271 |
| Popis: | WOS: 000384427500009 PubMed ID: 27004711 Objective: The awareness, time in therapeutic range (TTR), and safety of warfarin therapy were investigated in the adult Turkish population. Methods: This multicenter prospective study includes 4987 patients using warfarin and involved regular international normalized ratio (INR) monitoring between January 1, 2014 and December 31, 2014. TTR was calculated according to F.R. Roosendaal's algorithm. Awareness was evaluated based on the patients' knowledge of warfarin's affect and food-drug interactions. esults: The mean TTR of patients was 49.52 +/- 22.93%. The patients with hypertension (55.3%), coronary artery disease (23.2%), congestive heart failure (24.5%), or smoking habit (20.8%) had significantly lower TTR levels than the others. Of the total number of patients, 42.6% had a mechanical valve, 38.4% had non-valvular atrial fibrillation (AF), and 19% had other indications for warfarin. Patients with other indications had lower TTR levels than those with mechanical valve and non-valvular AF (p=0.018). Warfarin awareness decreased in higher age groups. The knowledge of warfarin's food-drug interactions was 55%. People with higher warfarin awareness had higher TTR levels. Patients with = 8 INR monitoring/year. In this study, 20.1% of the patients had a bleeding event (major bleeding 15.8%, minor bleeding 84.2%) within a year. Conclusion: Both the mean TTR ratios and awareness of the Turkish population on warfarin therapy were found to be low. It was thought that low TTR levels of the Turkish population may be caused by the low awareness of warfarin, warfarin's food-drug interactions, and high rates of concomitant diseases. |
| Databáze: | OpenAIRE |
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