The serotonin-4 receptor agonist cisapride and angiotensin-II exert additive effects on aldosterone secretion in normal man
| Autor: | J M Kuhn, H Lefebvre, C Delarue, Hubert Vaudry, V Contesse, L. M. Wolf, A Legrand |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Agonist medicine.medical_specialty medicine.drug_class Renal glomerulus Endocrinology Diabetes and Metabolism food.diet Clinical Biochemistry Peptide hormone Low sodium diet Pharmacology Biochemistry chemistry.chemical_compound Endocrinology food Piperidines Reference Values Internal medicine Renin–angiotensin system medicine Humans Aldosterone Cisapride Angiotensin II Biochemistry (medical) Drug Synergism Diet Sodium-Restricted Serotonin Receptor Agonists chemistry medicine.drug |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 80:504-507 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.80.2.7852511 |
| Popis: | In animals and man, serotonin (5-HT) exerts a direct stimulatory action on adrenocortical cells through activation of 5-HT4 receptors. In rats, 5-HT also potentiates the stimulatory effect of angiotensin-II (Ang II) on aldosterone secretion. The aim of the present study was to investigate the effect of concomitant administration of the 5-HT4 receptor agonist, cisapride, and Ang II on aldosterone secretion in normal human subjects. Eight healthy male volunteers pretreated with dexamethasone received, at 1-week intervals in random order and simple blind fashion, the following treatments: 1) a single oral dose of 10 mg cisapride, 2) a single oral dose of placebo, 3) a perfusion of graded doses of Ang II (from 1-4 ng/kg.min), 4) a perfusion of placebo, and 5) a single oral dose of 10 mg cisapride associated with a perfusion of Ang II. The oral doses of cisapride and placebo were also administered after a 3-day period of a low sodium diet (10 mmol/day). Plasma aldosterone levels increased significantly within 90 min after the administration of cisapride without any change in renin levels. The comparison between the net increase in aldosterone production induced by cisapride, Ang II, and cisapride plus Ang II showed that the stimulatory effects of cisapride and Ang II on aldosterone secretion were only additive. Similarly, the increase in plasma aldosterone levels induced by a sodium-restricted diet was just additive with the cisapride-evoked stimulation of aldosterone secretion. These results provide further evidence that the action of 5-HT on glomerulosa cells is mediated through activation of 5-HT4 receptors. The data also indicate that in humans, 5-HT does not potentiate the stimulatory effect of Ang II on aldosterone secretion. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|