Protective effect of Nigella sativa oil against binge ethanol-induced oxidative stress and liver injury in rats
| Autor: | Gül Özdemirler Erata, Necla Koçak-Toker, Seval Develi, Esra Betül Kalaz, Betül Evran |
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| Rok vydání: | 2013 |
| Předmět: |
Antioxidant
medicine.medical_treatment Nigella sativa Pharmacology medicine.disease_cause Protective Agents Transaminase Rats Sprague-Dawley chemistry.chemical_compound Malondialdehyde Drug Discovery Botany medicine Animals Humans Plant Oils Liver Diseases Alcoholic Transaminases Liver injury Triglyceride Vitamin C Ethanol Superoxide Dismutase General Medicine medicine.disease Rats Disease Models Animal Oxidative Stress Complementary and alternative medicine chemistry Liver Female Oxidative stress |
| Zdroj: | Chinese journal of natural medicines. 12(7) |
| ISSN: | 1875-5364 |
| Popis: | Aim Nigella sativa L. (Ranunculaceae) is considered as a therapeutic plant-based medicine for liver damage. In this study, the aim was to study the effect of Nigella sativa oil (NSO) pretreatment on ethanol-induced hepatotoxicity in rats. Method Rats were given Nigella sativa oil at doses of 2.5 and 5.0 mL·kg −1 , orally for 3 weeks, followed by oral ethanol (EtOH) administration (5 g·kg −1 ) every 12 h three times (binge model). Results Binge ethanol application caused significant increases in plasma transaminase activities and hepatic triglyceride and malondialdehyde (MDA) levels. It decreased hepatic glutathione (GSH) levels, but did not change vitamins E and vitamin C levels and antioxidant enzyme activities. NSO (5.0 mL·kg −1 ) pretreatment significantly decreased plasma transaminase activities, hepatic MDA, and triglyceride levels together with amelioration in hepatic histopathological findings. Conclusion NSO pretreatment may be effective in protecting oxidative stress-induced hepatotoxicity after ethanol administration |
| Databáze: | OpenAIRE |
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