Prophylactic cranial irradiation in small cell lung cancer: a single institution experience
| Autor: | D. Hacking, J. Naidoo, M. Kehoe, W. Sasiadek, Paula Calvert |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Lung Neoplasms Time Factors Cell Disease Kaplan-Meier Estimate Disease-Free Survival Risk Factors medicine Carcinoma Humans cardiovascular diseases Extensive stage Aged Retrospective Studies Lung business.industry Brain Neoplasms Incidence General Medicine Middle Aged medicine.disease Small Cell Lung Carcinoma Surgery surgical procedures operative medicine.anatomical_structure Treatment Outcome Conventional PCI Female Radiology Prophylactic cranial irradiation Cranial Irradiation business therapeutics Ireland |
| Zdroj: | Irish journal of medical science. 183(1) |
| ISSN: | 1863-4362 |
| Popis: | Prophylactic cranial irradiation (PCI) is used to prevent the development of brain metastases in small cell lung carcinoma. PCI confers an overall survival (OS) benefit in both limited and extensive stage disease.We analyze the incidence of symptomatic brain metastases, progression-free survival (PFS) and OS in a cohort of patients who received PCI, in a 5-year period.A retrospective review of all patients who had received PCI between 2006 and 2011 at the Whitfield Clinic was completed. Patient- and disease-related characteristics, the number of patients who developed brain metastases, PFS and OS data were collected.24 patients were identified. 14 (58.3 %) patients were male, 10 (41.7 %) were female, with a mean age of 62.5 years (range 31-78). All patients were smokers. 12 (50 %) patients had limited stage small cell lung cancer (SCLC), 12 (50 %) had extensive stage disease. 2 (8.2 %) patients developed brain metastases post PCI (p = 0.478.) The median PFS for limited stage SCLC was 13 months (range 3-20) and 10 months (range 5-18) for extensive stage SCLC. Median OS was 15 months (range 4-29) in limited stage SCLC, and 11 months (range 5-29) in extensive stage SCLC.Our study demonstrated a low incidence of symptomatic brain metastases and favourable median PFS and OS in the patients that received PCI, when compared to published phase III data. |
| Databáze: | OpenAIRE |
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