Common variants predict recurrence after nonfamilial atrial fibrillation ablation in Chinese Han population
| Autor: | Haiqing Wu, Juan Xu, Zujia Wen, Shaowen Liu, Chun-kai Huang, Li-qun Zhao, Guo-bing Zhang, Zhi-min Wang, Baozhen Qi, Yongyong Shi |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology Male medicine.medical_specialty China Genotype medicine.medical_treatment Genome-wide association study Catheter ablation Single-nucleotide polymorphism 030204 cardiovascular system & hematology Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Asian People Recurrence Internal medicine Atrial Fibrillation Medicine Humans Genetic Predisposition to Disease Risk factor Survival analysis Aged business.industry Proportional hazards model Atrial fibrillation Middle Aged medicine.disease Ablation Survival Analysis 030104 developmental biology Logistic Models Case-Control Studies Cardiology Catheter Ablation Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | International journal of cardiology. 227 |
| ISSN: | 1874-1754 |
| Popis: | Background Genome-wide association studies (GWAS) have identified several loci associated with atrial fibrillation (AF) and have been reportedly associated with response to catheter ablation for AF in patients of European ancestry; however, associations between susceptibility loci and clinical recurrence of AF after catheter ablation have not been examined in Chinese Han populations. To the personalization of catheter ablation for AF, we examined whether these single nucleotide polymorphisms (SNPs) can predict clinical outcomes after catheter ablation for AF in Chinese Han population. Methods and results The association between 8 SNPs and AF was studied in 1418 AF patients and 1424 controls by the unconditional logistic regression analysis. The survival analyses were used to compare AT/AF recurrence differences among 438 AF patients, which were classified by the genotype of rs2200733. rs2200733 and rs6590357 were significantly associated with AF in Chinese Han population. In addition, rs2200733 was associated with clinical recurrence of AF after catheter ablation. In Kaplan–Meier survival analysis, the recurrence-free rates for AF with TT and with TC+CC were 35.5% and 61.9%, respectively ( P =0.0009). In multivariate Cox regression analysis, rs2200733 was strong independent risk factor for recurrence. Conclusion rs2200733 risk allele at the 4q25 predicted impaired clinical response to catheter ablation for AF in Chinese Han population. Our findings suggested rs2200733 polymorphism may be used as a clinical tool for selection of patients for AF catheter ablation. |
| Databáze: | OpenAIRE |
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