Tissue extravasation of albumin from intraabdominal trauma in rats
| Autor: | B. Lisander, G. Akerström |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Pathology medicine.medical_specialty Serum albumin Abdominal Injuries Abdominal wall medicine Animals Tissue Distribution Serum Albumin Radio-Iodinated Radionuclide Imaging Serum Albumin biology business.industry Albumin Rats Inbred Strains General Medicine medicine.disease Extravasation Small intestine Rats Anesthesiology and Pain Medicine medicine.anatomical_structure Abdominal trauma biology.protein Abdomen business Abdominal surgery |
| Zdroj: | Acta Anaesthesiologica Scandinavica. 35:257-261 |
| ISSN: | 1399-6576 0001-5172 |
| DOI: | 10.1111/j.1399-6576.1991.tb03284.x |
| Popis: | Intraabdominal surgery tends to lower circulating plasma volume by mechanisms unrelated to bleeding and evaporation. In chloralose-anesthetized rats, the tissue clearance of radiolabelled albumin was determined by a double isotope method. Animals were subjected to a standardized abdominal trauma, eliciting minimal bleeding and evaporation, and others served as controls. The trauma significantly increased tissue albumin extravasation in abdominal skin, abdominal wall, pancreas, small intestine, colon, mesentery and diaphragm. Considering the mass of the respective tissues, a substantial portion of the albumin extravasation took place in the abdominal wall. No increased albumin clearance was found in extra-abdominal tissues. It is suggested that abdominal surgery decreases plasma volume by extravasation in the operation field. |
| Databáze: | OpenAIRE |
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