Primary resistance to clarithromycin in clinical strains of Helicobacter pylori isolated from children in Poland
| Autor: | Paulina Jóźwiak, Elzbieta Rozynek, Danuta Dzierzanowska, Katarzyna Dzierżanowska-Fangrat, Kazimierz Madaliński, Danuta Celinska-Cedro |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Microbiology (medical)
Male Adolescent medicine.drug_class Spirillaceae Antibiotics Microbial Sensitivity Tests Polymerase Chain Reaction Microbiology Helicobacter Infections Minimum inhibitory concentration 23S ribosomal RNA Clarithromycin Drug Resistance Bacterial medicine Humans Point Mutation Pharmacology (medical) Child Antibacterial agent biology Helicobacter pylori Point mutation General Medicine bacterial infections and mycoses biology.organism_classification RNA Bacterial RNA Ribosomal 23S Infectious Diseases Female Poland Polymorphism Restriction Fragment Length medicine.drug |
| Zdroj: | International journal of antimicrobial agents. 18(4) |
| ISSN: | 0924-8579 |
| Popis: | Helicobacter pylori resistance to clarithromycin is an important factor in the failure of eradication therapy. The resistance results from point mutations in the 23S rRNA gene of H. pylori. The prevalence of primary resistance of H. pylori to clarithromycin in children and mutations associated with resistance were studied and it was found that 23.5% (23/98) of H. pylori strains isolated in our hospital during 1998–2000 were resistant to clarithromycin. The primary resistance was mainly caused by an A2143G mutation, but the isolates with an A2142G mutation had higher MICs for clarithromycin compared with those with an A2143G mutation: median MIC 256 versus 16 mg/l. Comparison of our data with previous results showed that the prevalence of H. pylori resistance to clarithromycin in children has increased in Poland over the last three years, however the difference was not significant (23.5 vs. 17%, P=0.22). |
| Databáze: | OpenAIRE |
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